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Endocytosis of hepatitis C virus non-enveloped capsid-like particles induces MAPK-ERK1/2 signaling events
dc.creator | Katsarou, K. | en |
dc.creator | Lavdas, A. A. | en |
dc.creator | Tsitoura, P. | en |
dc.creator | Serti, E. | en |
dc.creator | Markoulatos, P. | en |
dc.creator | Mavromara, P. | en |
dc.creator | Georgopoulou, U. | en |
dc.date.accessioned | 2015-11-23T10:34:12Z | |
dc.date.available | 2015-11-23T10:34:12Z | |
dc.date.issued | 2010 | |
dc.identifier | 10.1007/s00018-010-0351-5 | |
dc.identifier.issn | 1420-682X | |
dc.identifier.uri | http://hdl.handle.net/11615/29253 | |
dc.description.abstract | Although HCV is an enveloped virus, naked nucleocapsids have been reported in the serum of infected patients. The HCV core particle serves as a protective capsid shell for the viral genome and recombinant in vitro assembled HCV core particles induce strong specific immunity. We investigated the post-binding mechanism of recombinant core particle uptake and its intracellular fate. In hepatic cells, these particles are internalized, most likely in a clathrin-dependent pathway, reaching early to late endosomes and finally lysosomes. The endocytic acidic milieu is implicated in trafficking process. Using specific phosphoantibodies, signaling pathway inhibitors and chemical agents, ERK(1/2) was found to be activated in a sustained way after endocytosis, followed by downstream immediate early genes (c-fos and egr-1) modulation. We propose that the intriguing properties of cellular internalization of HCV non-enveloped particles can induce specific ERK(1/2)-MAPKs events that could be important in HCV life cycle and pathogenesis of HCV infection. | en |
dc.source | Cellular and Molecular Life Sciences | en |
dc.source.uri | <Go to ISI>://WOS:000279025400012 | |
dc.subject | Hepatitis C virus | en |
dc.subject | Non-enveloped particles | en |
dc.subject | Endocytosis | en |
dc.subject | ERK(1/2) | en |
dc.subject | c-fos | en |
dc.subject | egr-1 | en |
dc.subject | CLATHRIN-MEDIATED ENDOCYTOSIS | en |
dc.subject | EARLY GENE-PRODUCTS | en |
dc.subject | HCV CORE PROTEIN | en |
dc.subject | IN-VITRO | en |
dc.subject | MAP KINASE | en |
dc.subject | HEPATOCELLULAR-CARCINOMA | en |
dc.subject | TRANSCRIPTION FACTOR | en |
dc.subject | INFECTED PATIENTS | en |
dc.subject | CELLULAR UPTAKE | en |
dc.subject | EARLY ENDOSOMES | en |
dc.subject | Biochemistry & Molecular Biology | en |
dc.subject | Cell Biology | en |
dc.title | Endocytosis of hepatitis C virus non-enveloped capsid-like particles induces MAPK-ERK1/2 signaling events | en |
dc.type | journalArticle | en |
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