Novel conformationally constrained pyrazole derivatives as potential anti-cancer agents
dc.creator | Kasiotis, K. M. | en |
dc.creator | Tzanetou, E. N. | en |
dc.creator | Stagos, D. | en |
dc.creator | Fokialakis, N. | en |
dc.creator | Koutsotheodorou, E. | en |
dc.creator | Kouretas, D. | en |
dc.creator | Haroutounian, S. A. | en |
dc.date.accessioned | 2015-11-23T10:33:57Z | |
dc.date.available | 2015-11-23T10:33:57Z | |
dc.date.issued | 2015 | |
dc.identifier | 10.1515/znb-2015-0053 | |
dc.identifier.issn | 0932-0776 | |
dc.identifier.uri | http://hdl.handle.net/11615/29191 | |
dc.description.abstract | The synthesis of 17 novel conformationally constrained pyrazole derivatives is reported herein, along with the assessment of their anti-proliferative and anti-angiogenic activities. The evaluation of their inhibitory effect on cell proliferation against HepG2, HeLa, and MCF-7 cells revealed the pyrrolo[2,3-g]indazole 23 as a potent inhibitor of cell growth with IC50 values of 5 mu m. Additionally, the inhibition of vascular endothelial growth factor by pyrazoles 20 and 23 (30 % and 35 %, respectively) in HeLa supernatant cells was evidenced. These findings highlight the usefulness of these compounds as potential scaffolds for the design and development of novel anticancer agents with pronounced anti-angiogenic activity. | en |
dc.source.uri | <Go to ISI>://WOS:000360529000010 | |
dc.subject | angiogenesis | en |
dc.subject | anti-cancer agents | en |
dc.subject | anti-proliferative | en |
dc.subject | pyrazoles | en |
dc.subject | synthesis | en |
dc.subject | BREAST-CANCER AGENTS | en |
dc.subject | ESTROGEN-RECEPTOR | en |
dc.subject | BIOLOGICAL EVALUATION | en |
dc.subject | IN-VITRO | en |
dc.subject | LIGANDS | en |
dc.subject | DESIGN | en |
dc.subject | Chemistry, Inorganic & Nuclear | en |
dc.subject | Chemistry, Organic | en |
dc.title | Novel conformationally constrained pyrazole derivatives as potential anti-cancer agents | en |
dc.type | journalArticle | en |
Αρχεία σε αυτό το τεκμήριο
Αρχεία | Μέγεθος | Τύπος | Προβολή |
---|---|---|---|
Δεν υπάρχουν αρχεία που να σχετίζονται με αυτό το τεκμήριο. |