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Superficial Vein Thrombosis in Patients with Varicose Veins: Role of Thrombophilia Factors, Age and Body Mass
dc.creator | Karathanos, C. | en |
dc.creator | Sfyroeras, G. | en |
dc.creator | Drakou, A. | en |
dc.creator | Roussas, N. | en |
dc.creator | Exarchou, M. | en |
dc.creator | Kyriakou, D. | en |
dc.creator | Giannoukas, A. D. | en |
dc.date.accessioned | 2015-11-23T10:33:34Z | |
dc.date.available | 2015-11-23T10:33:34Z | |
dc.date.issued | 2012 | |
dc.identifier | 10.1016/j.ejvs.2011.12.019 | |
dc.identifier.issn | 1078-5884 | |
dc.identifier.uri | http://hdl.handle.net/11615/29110 | |
dc.description.abstract | Objectives: To investigate the association of various risk factors including thrombophilia defects, in patients with varicose veins (VVs) and history of episodes of superficial vein thrombosis (SVT). Materials and methods: Two hundred and thirty patients with primary VVs were included in this prospective study. A total of 128 (43 men, age 56 +/- 13) had an acute episode or a previous history of SVT, while 102 patients (27 men, age 48 +/- 12) did not. Coagulation profile investigation included serum levels of protein C (PC), protein S (PS), anti-thrombin III (AT III), plasminogen (Plg), A(2) antiplasmin (A(2)Apl) and activated protein C resistance (APCR). This was performed at least 3 months after the SVT episode to ensure that the results were not altered. Age and body mass index (BMI) were also assessed. Results: PC deficiency was detected in 3/128 (2.3%), PS deficiency in 19/128 (14.8%), AT III deficiency in 29/128 (22.7%), Pig deficiency in 9/128 (7%), A(2)Apl excess in 3/128 (2.3%) and APCR in 9/128 (7%) patients with SVT and 0/102 (0%), 3/102 (2.9%), 15/102 (14.7%), 6/102 (5.8%), 0/102 (0%) and 1/102 (0.9%) in the control group, respectively. BMI greater than 30 kg m(-2) was associated with SVT. In logistic regression analysis SVT was associated with PS deficiency (odds ratio (OR) 6.7, p = 0.004, 95% confidence interval (CI) 1.83-24.53), obesity (OR 3.5, p = 0.003, 95% CI 1.53-8.05) and age (OR 1.038, p = 0.001, 95% CI 1.01-1.06). Conclusions: Obesity, age and PS deficiency were found as factors associated with SVT episodes in patients with VVs. (C) 2011 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved. | en |
dc.source | European Journal of Vascular and Endovascular Surgery | en |
dc.source.uri | <Go to ISI>://WOS:000302200100023 | |
dc.subject | Superficial vein thrombosis | en |
dc.subject | Varicose veins | en |
dc.subject | Thrombophilia | en |
dc.subject | Protein S | en |
dc.subject | deficiency | en |
dc.subject | Obesity | en |
dc.subject | Body mass | en |
dc.subject | PROTEIN-S DEFICIENCY | en |
dc.subject | GENETIC RISK-FACTORS | en |
dc.subject | FACTOR-V-LEIDEN | en |
dc.subject | VENOUS | en |
dc.subject | THROMBOSIS | en |
dc.subject | CLINICAL-MANIFESTATIONS | en |
dc.subject | SURGICAL-TREATMENT | en |
dc.subject | ANTITHROMBIN-III | en |
dc.subject | C RESISTANCE | en |
dc.subject | LOWER-LIMBS | en |
dc.subject | THROMBOPHLEBITIS | en |
dc.subject | Surgery | en |
dc.subject | Peripheral Vascular Disease | en |
dc.title | Superficial Vein Thrombosis in Patients with Varicose Veins: Role of Thrombophilia Factors, Age and Body Mass | en |
dc.type | journalArticle | en |
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