Εμφάνιση απλής εγγραφής

dc.creatorKaragiannis, G.en
dc.creatorGrivas, I.en
dc.creatorTsingotjidou, A. S.en
dc.creatorApostolidis, G.en
dc.creatorGrigoriadou, I.en
dc.creatorDori, I.en
dc.creatorPoulatsidou, K. N.en
dc.creatorDoumas, A.en
dc.creatorWesarg, S.en
dc.creatorGeorgoulias, P.en
dc.date.accessioned2015-11-23T10:32:58Z
dc.date.available2015-11-23T10:32:58Z
dc.date.issued2015
dc.identifier10.1117/12.2079690
dc.identifier.isbn9781628414134
dc.identifier.issn16057422
dc.identifier.urihttp://hdl.handle.net/11615/28955
dc.description.abstractMalignant melanoma is a form of skin cancer, with increasing incidence worldwide. Early diagnosis is crucial for the prognosis and treatment of the disease. The objective of this study is to develop a novel animal model of melanoma and apply a combination of the non-invasive imaging techniques acoustic microscopy, infrared (IR) and Raman spectroscopies, for the detection of developing tumors. Acoustic microscopy provides information about the 3D structure of the tumor, whereas, both spectroscopic modalities give qualitative insight of biochemical changes during melanoma development. In order to efficiently set up the final devices, propagation of ultrasonic and electromagnetic waves in normal skin and melanoma simulated structures was performed. Synthetic and grape-extracted melanin (simulated tumors), endermally injected, were scanned and compared to normal skin. For both cases acoustic microscopy with central operating frequencies of 110MHz and 175MHz were used, resulting to the tomographic imaging of the simulated tumor, while with the spectroscopic modalities IR and Raman differences among spectra of normal and melanin-injected sites were identified in skin depth. Susequently, growth of actual tumors in an animal melanoma model, with the use of human malignant melanoma cells was achieved. Acoustic microscopy and IR and Raman spectroscopies were also applied. The development of tumors at different time points was displayed using acoustic microscopy. Moreover, the changes of the IR and Raman spectra were studied between the melanoma tumors and adjacent healthy skin. The most significant changes between healthy skin and the melanoma area were observed in the range of 900-1800cm-1 and 350-2000cm-1, respectively. © 2015 SPIE.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84928526632&partnerID=40&md5=a5fd184c0d78b3bbb5e79d0671ea1f16
dc.subjectAcoustic microscopyen
dc.subjectAnimal model of human melanomaen
dc.subjectEarly Diagnosisen
dc.subjectInfrared and Raman spectroscopyen
dc.subjectMalignant melanomaen
dc.subjectNon-invasive techniquesen
dc.subjectAcoustic microscopesen
dc.subjectAcoustic spectroscopyen
dc.subjectAcoustic variables measurementen
dc.subjectAnimalsen
dc.subjectBioacousticsen
dc.subjectDermatologyen
dc.subjectDiseasesen
dc.subjectElectromagnetic wavesen
dc.subjectImaging techniquesen
dc.subjectMelaninen
dc.subjectOncologyen
dc.subjectPhotonsen
dc.subjectRaman spectroscopyen
dc.subjectTumorsen
dc.subjectUltrasonic applicationsen
dc.subjectAnimal modelen
dc.subjectNoninvasive techniqueen
dc.subjectDiagnosisen
dc.titleEarly detection of melanoma with the combined use of acoustic microscopy, infrared reflectance and Raman spectroscopyen
dc.typeconferenceItemen


Αρχεία σε αυτό το τεκμήριο

ΑρχείαΜέγεθοςΤύποςΠροβολή

Δεν υπάρχουν αρχεία που να σχετίζονται με αυτό το τεκμήριο.

Αυτό το τεκμήριο εμφανίζεται στις ακόλουθες συλλογές

Εμφάνιση απλής εγγραφής