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dc.creatorKarachalios, T.en
dc.creatorBoursinos, L.en
dc.creatorPoultsides, L.en
dc.creatorKhaldi, L.en
dc.creatorMalizos, K. N.en
dc.date.accessioned2015-11-23T10:32:48Z
dc.date.available2015-11-23T10:32:48Z
dc.date.issued2007
dc.identifier10.1302/0301-620x.89b9.19050
dc.identifier.issn0301-620X
dc.identifier.urihttp://hdl.handle.net/11615/28918
dc.description.abstractWe have evaluated the effect of the short-term administration of low therapeutic doses of modern COX-2 inhibitors on the healing of fractures. A total of 40 adult male New Zealand rabbits were divided into five groups. A mid-diaphyseal osteotomy of the right ulna was performed and either normal saline, prednisolone, indometacin, meloxicam or rofecoxib was administered for five days. Radiological, biomechanical and histomorphometric evaluation was performed at six weeks. In the group in which the highly selective anti-COX-2 agent, rofecoxib, was used the incidence of radiologically-incomplete union was similar to that in the control group. All the biomechanical parameters were statistically significantly lower in both the prednisolone and indometacin (p = 0.01) and in the meloxicam (p = 0.04) groups compared with the control group. Only the fracture load values were found to be statistically significantly lower (p = 0.05) in the rofecoxib group. Histomorphometric parameters were adversely affected in all groups with the specimens of the rofecoxib group showing the least negative effect. Our findings indicated that the short-term administration of low therapeutic doses of a highly selective COX-2 inhibitor had a minor negative effect on bone healing.en
dc.sourceJournal of Bone and Joint Surgery-British Volumeen
dc.source.uri<Go to ISI>://WOS:000249935300025
dc.subjectNONSTEROIDAL ANTIINFLAMMATORY DRUGSen
dc.subjectCYCLOOXYGENASE-2 INHIBITORSen
dc.subjectOSTEOTOMY MODELen
dc.subjectSPINAL-FUSIONen
dc.subjectBONEen
dc.subjectRATSen
dc.subjectINDOMETHACINen
dc.subjectPHARMACOKINETICSen
dc.subjectCORTICOSTEROIDSen
dc.subjectROFECOXIBen
dc.subjectOrthopedicsen
dc.subjectSurgeryen
dc.titleThe effects of the short-term administration of low therapeutic doses of anti-COX-2 agents on the healing of fractures - An experimental study in rabbitsen
dc.typejournalArticleen


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