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Growth hormone response to thyrotrophin releasing hormone in women with polycystic ovarian syndrome
dc.creator | Kaltsas, T. | en |
dc.creator | Pontikides, N. | en |
dc.creator | Krassas, G. E. | en |
dc.creator | Seferiadis, K. | en |
dc.creator | Lolis, D. | en |
dc.creator | Messinis, I. E. | en |
dc.date.accessioned | 2015-11-23T10:31:12Z | |
dc.date.available | 2015-11-23T10:31:12Z | |
dc.date.issued | 1999 | |
dc.identifier | 10.1093/humrep/14.11.2704 | |
dc.identifier.issn | 0268-1161 | |
dc.identifier.uri | http://hdl.handle.net/11615/28802 | |
dc.description.abstract | Recent clinical studies have suggested that women with polycystic ovarian syndrome (PCOS) may have disturbances of growth hormone (GH) kinetics and the GH/insulin-like growth factor (IGF)-I system. The knowledge that in various metabolic abnormalities there is a paradoxical sensitivity of pituitary somatotrophs to thyrotrophin-releasing hormone (TRH) administration led to this investigation of the GH secretory response to TRH in women with PCOS, Twenty-four women with PCOS and 18 control women were studied. TRH was given as a single i.v. injection (time 0) and blood samples for GH measurements were obtained at -15, 0, 15, 30, 60 and 90 min. The GH responses were expressed as the area under the curve (AUC) or the differences from the basal value (Delta max), The GH response to TRH(mean +/- SEM) was greater in women with PCOS (Delta max 2.47 +/- 1.73 versus 0.47 +/- 0.06 ng/ml, P < 0.05 and GH AUC 8.05 +/- 2.10 versus 2.58 +/- 0.18 ng/ ml/90 min, P < 0.05), According to GH response to TRH, two PCOS subgroups were identified: (i) normal responders (n = 14) who showed Delta max GH response (0.36 +/- 0.06 ng/ml)and GH AUC (1.93 +/- 0.64 ng/ml/90 min) similar to that in the controls and (ii) over-responders (n +/- 10) who showed a paradoxical increase in GH concentrations in response to TRH Delta max GH response 5.43 +/- 1.27 ng/ml and GH AUC 16.62 +/- 3.51 ng/ml per 90 min) that was significantly higher than in normally responding PCOS patients (P < 0.0001) or in controls (P < 0.0001), These data demonstrate an enhanced GH response to TRH administration in a subgroup of women with PCOS. | en |
dc.source | Human Reproduction | en |
dc.source.uri | <Go to ISI>://WOS:000083600200006 | |
dc.subject | growth hormone | en |
dc.subject | insulin | en |
dc.subject | insulin-like growth factor-I | en |
dc.subject | polycystic | en |
dc.subject | ovarian syndrome | en |
dc.subject | thyrotrophin releasing hormone | en |
dc.subject | THYROID-STIMULATING HORMONE | en |
dc.subject | FACTOR-I AXIS | en |
dc.subject | GRANULOSA-CELLS | en |
dc.subject | L-DOPA | en |
dc.subject | SECRETION | en |
dc.subject | INSULIN | en |
dc.subject | GONADOTROPINS | en |
dc.subject | PROLACTIN | en |
dc.subject | INHIBITION | en |
dc.subject | INDUCTION | en |
dc.subject | Obstetrics & Gynecology | en |
dc.subject | Reproductive Biology | en |
dc.title | Growth hormone response to thyrotrophin releasing hormone in women with polycystic ovarian syndrome | en |
dc.type | journalArticle | en |
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