dc.creator | Kaditis, A. G. | en |
dc.creator | Alexopoulos, E. I. | en |
dc.creator | Kalampouka, E. | en |
dc.creator | Hatzi, F. | en |
dc.creator | Karadonta, I. | en |
dc.creator | Kyropoulos, T. | en |
dc.creator | Kaditis, D. G. | en |
dc.creator | Gourgoulianis, K. | en |
dc.creator | Syrogiannopoulos, G. A. | en |
dc.date.accessioned | 2015-11-23T10:30:41Z | |
dc.date.available | 2015-11-23T10:30:41Z | |
dc.date.issued | 2007 | |
dc.identifier | 10.1007/s11325-007-0117-y | |
dc.identifier.issn | 15209512 | |
dc.identifier.uri | http://hdl.handle.net/11615/28679 | |
dc.description.abstract | Hypoxia promotes adherence of leukocytes to endothelial cells by inducing expression of adhesion molecules like intercellular adhesion molecule 1 (ICAM-1). Increased serum levels of circulating ICAM-1 (cICAM-1) have been reported in adults with sleep apnea and associated hypoxemia. This investigation assessed the hypothesis that the overnight change of cICAM-1 levels in children with snoring is correlated with the severity of obstructive sleep-disordered breathing. Evening and morning serum levels of cICAM-1 were measured in children with snoring referred for polysomnography. Twenty-five children with an apnea - hypopnea index greater than or equal to 5 episodes/h (5.5 ± 1.8 years), 30 subjects with an index less than 5 and greater than 1 (6.3 ± 2 years), and 19 children with an index less than or equal to 1 (7.1 ± 3 years) were recruited. Overnight change in cICAM-1 (log-transformed ratio of morning-to-evening levels) was similar in subjects with an apnea - hypopnea index greater than or equal to 5 episodes/h compared to those with an index less than 5 and greater than 1 or to children with an index less than or equal to 1 (-0.001 ± 0.08 vs -0.03 ± 0.09 vs -0.06 ± 0.1; p > 0.05). When multiple regression analysis was applied, apnea - hypopnea index, respiratory arousal index, and oxygen saturation of hemoglobin nadir were not significant predictors of overnight change in cICAM-1 levels. Thus, in children with snoring, overnight change in cICAM-1 levels is not related to severity of obstructive sleep-disordered breathing. © Springer-Verlag 2007. | en |
dc.source.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-35748978210&partnerID=40&md5=9e716419fc5af79d661c7b9197e272ed | |
dc.subject | Atherosclerosis | en |
dc.subject | Inflammation | en |
dc.subject | Intercellular adhesion molecules | en |
dc.subject | Obstructive sleep apnea | en |
dc.subject | Snoring | en |
dc.subject | intercellular adhesion molecule 1 | en |
dc.subject | adolescent | en |
dc.subject | article | en |
dc.subject | child | en |
dc.subject | circadian rhythm | en |
dc.subject | controlled study | en |
dc.subject | correlation analysis | en |
dc.subject | disease severity | en |
dc.subject | female | en |
dc.subject | human | en |
dc.subject | hypothesis | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | oxygen saturation | en |
dc.subject | polysomnography | en |
dc.subject | prediction | en |
dc.subject | priority journal | en |
dc.subject | protein blood level | en |
dc.subject | rating scale | en |
dc.subject | sleep apnea syndrome | en |
dc.subject | Humans | en |
dc.subject | Intercellular Adhesion Molecule-1 | en |
dc.subject | Severity of Illness Index | en |
dc.subject | Sleep Apnea, Obstructive | en |
dc.title | Nocturnal change of circulating intercellular adhesion molecule 1 levels in children with snoring | en |
dc.type | journalArticle | en |