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Urine Levels of Catecholamines in Greek Children With Obstructive Sleep-Disordered Breathing
dc.creator | Kaditis, A. G. | en |
dc.creator | Alexopoulos, E. I. | en |
dc.creator | Damani, E. | en |
dc.creator | Hatzi, F. | en |
dc.creator | Chaidas, K. | en |
dc.creator | Kostopoulou, T. | en |
dc.creator | Tzigeroglou, A. | en |
dc.creator | Gourgoulianis, K. | en |
dc.date.accessioned | 2015-11-23T10:30:40Z | |
dc.date.available | 2015-11-23T10:30:40Z | |
dc.date.issued | 2009 | |
dc.identifier | 10.1002/ppul.20916 | |
dc.identifier.issn | 8755-6863 | |
dc.identifier.uri | http://hdl.handle.net/11615/28674 | |
dc.description.abstract | Introduction: Adults with obstructive sleep apnea have increased sympathetic activity It was hypothesized that in children with symptoms of obstructive sleep-disordered breathing (SDB), morning urine levels of catecholamines correlate with severity of nocturnal hypoxemia. Methods: Children with snoring referred for polysomnography and controls without snoring were recruited. Morning urine norepinephrine, epinephrine, normetanephrine, and metanephrine levels were measured (ng/mg urine creatinine). Results: Twelve children (age 5.2 +/- 2.3 years) with severe hypoxemia (oxygen saturation of hemoglobin-SpO(2) nadir <= 86%), 20 subjects (age 6.1 +/- 2.1 years) with moderate hypoxemia (SpO(2) nadir <= 90% and > 86%), 22 children (age 6.6 +/- 1.5 years) with mild nocturnal hypoxemia (SpO(2) nadir > 90%), and 10 controls (age 7.1 +/- 2.8 years) were studied. Children with severe hypoxemia had significantly higher log-transformed norepinephrine levels (1.63 +/- 0.29) compared to those with moderate hypoxemia (1.43 +/- 0.22; P < 0.05) or compared to controls (1.39 +/- 0.31; P < 0.05). In subjects with SDB, log-transformed oxygen desaturation of hemoglobin index or SpO(2) nadir predicted log-transformed norepinephrine levels after adjustment by age, gender and body mass index (r(2) = 0.24; and r(2) = 0.24, respectively; P < 0.01). Conclusions: Severity of nocturnal hypoxemia in children with intermittent upper airway obstruction during sleep correlates with morning urine levels of norepinephrine suggesting increased sympathetic tone. Pediatr Pulmonol. 2009;44:38-45. (c) 2008 Wiley-Liss, Inc. | en |
dc.source.uri | <Go to ISI>://WOS:000262386100005 | |
dc.subject | atherosclerosis | en |
dc.subject | blood pressure | en |
dc.subject | hypoxemia | en |
dc.subject | obstructive sleep apnea | en |
dc.subject | sympathetic tone | en |
dc.subject | NERVOUS-SYSTEM ACTIVITY | en |
dc.subject | C-REACTIVE PROTEIN | en |
dc.subject | BLOOD-PRESSURE | en |
dc.subject | SYMPATHETIC | en |
dc.subject | ACTIVITY | en |
dc.subject | APNEA SYNDROME | en |
dc.subject | NONOBESE CHILDREN | en |
dc.subject | OXIDATIVE STRESS | en |
dc.subject | STROKE | en |
dc.subject | VOLUME | en |
dc.subject | HYPOXIA | en |
dc.subject | INFLAMMATION | en |
dc.subject | Pediatrics | en |
dc.subject | Respiratory System | en |
dc.title | Urine Levels of Catecholamines in Greek Children With Obstructive Sleep-Disordered Breathing | en |
dc.type | journalArticle | en |
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