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dc.creatorKaditis, A.en
dc.creatorAlexopoulos, E.en
dc.creatorNtamagka, G.en
dc.creatorChaidas, K.en
dc.creatorKarathanasi, A.en
dc.creatorGougoura, S.en
dc.creatorPapathanasiou, A. A.en
dc.creatorLiakos, P.en
dc.creatorZintzaras, E.en
dc.creatorGourgoulianis, K.en
dc.date.accessioned2015-11-23T10:30:39Z
dc.date.available2015-11-23T10:30:39Z
dc.date.issued2010
dc.identifier10.1016/j.sleep.2009.03.013
dc.identifier.issn1389-9457
dc.identifier.urihttp://hdl.handle.net/11615/28670
dc.description.abstractBackground: Diminished nitric oxide (NO) levels have been reported in adults with obstructive sleep apnea but no data are available for children with obstructive sleep-disordered breathing (SDB). Objectives: To assess levels of serum NO metabolites in children with SDB and to explore the effects of NO metabolites, SDB and their interaction on blood pressure. Methods: Morning nitrite, the sum of nitrite and nitrate (NO), and the average of evening and morning blood pressure were assessed in children with SDB referred for polysomnography and in controls without SDB. Results: Forty-three children with SDB (age: 5.8 +/- 2.1 years) had moderate-to-severe nocturnal hypoxemia (SpO(2) nadir: 85.6 +/- 4%), 54 subjects (6.6 +/- 2.7 years) had mild hypoxemia (SpO(2) nadir: 91.4 +/- 1.3%) and 20 subjects were controls free of SDB (6.7 +/- 3.7 years). Subjects with moderate-to-severe hypoxemia had significantly lower In-transformed NO metabolites (1.4 +/- 0.7, nitrites; 2.6 +/- 0.5, NO(x)) compared to those with mild hypoxemia (1.9 +/- 0.8, nitrites; 3 +/- 0.6, NO(x)) and controls (2.2 +/- 0.7, nitrite; 3 +/- 0.6, NO(x); p<0.05). The effects of NO metabolites and SDB Or their interaction on blood pressure were not significant (p>0.05). Conclusions: Moderate-to-severe hypoxemia accompanying SDB is associated with reduced concentrations of morning serum NO metabolites, but NO levels do not seem to affect blood pressure. (C) 2010 Elsevier B.V. All rights reserved.en
dc.source.uri<Go to ISI>://WOS:000276118900008
dc.subjectBlood pressureen
dc.subjectNitrateen
dc.subjectNitric oxideen
dc.subjectNitriteen
dc.subjectSleep apneaen
dc.subjectEndotheliumen
dc.subjectAMBULATORY BLOOD-PRESSUREen
dc.subjectPOSITIVE AIRWAY PRESSUREen
dc.subjectC-REACTIVE PROTEINen
dc.subjectENDOTHELIAL FUNCTIONen
dc.subjectADHESION MOLECULESen
dc.subjectOXIDATIVE STRESSen
dc.subjectOXIDEen
dc.subjectSYNTHASEen
dc.subjectGREEK CHILDRENen
dc.subjectMORNING LEVELSen
dc.subjectAPNEA SYNDROMEen
dc.subjectClinical Neurologyen
dc.titleSerum nitrite and nitrate levels in children with obstructive sleep-disordered breathingen
dc.typejournalArticleen


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