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Gene expression profile of aquaporin 1 and associated interactors in malignant pleural mesothelioma

dc.creatorJagirdar, R.en
dc.creatorSolenov, E. I.en
dc.creatorHatzoglou, C.en
dc.creatorMolyvdas, P. A.en
dc.creatorGourgoulianis, K. I.en
dc.creatorZarogiannis, S. G.en
dc.date.accessioned2015-11-23T10:30:33Z
dc.date.available2015-11-23T10:30:33Z
dc.date.issued2013
dc.identifier10.1016/j.gene.2012.12.075
dc.identifier.issn0378-1119
dc.identifier.urihttp://hdl.handle.net/11615/28637
dc.description.abstractOverexpression of AQP1 has recently been shown to be an independent prognostic factor in pleural mesothelioma favoring survival. This paper presents a data mining and bioinformatics approach towards the evaluation of the gene expression profile of AQP1 in malignant pleural mesothelioma and of AQP1 associated markers in the context of mesothelioma disease phenotype, CDKN2A gene deletion, sex and asbestos exposure. The data generated were thus again subjected to differential expression profile analysis. Here we report that AQP1 is overexpressed in epithelioid mesothelioma and identify TRIP6 and EFEMP2 as candidate genes for further investigation in mesothelioma. (C) 2013 Elsevier B.V. All rights reserved.en
dc.source.uri<Go to ISI>://WOS:000315537800013
dc.subjectAquaporin-1en
dc.subjectGene expression profileen
dc.subjectMalignant pleural mesotheliomaen
dc.subjectPleural fluid transporten
dc.subjectProtein-protein interactionsen
dc.subjectCUTIS-LAXAen
dc.subjectPANCREATIC ADENOCARCINOMAen
dc.subjectP16/CDKN2A DELETIONen
dc.subjectPROGNOSTIC-FACTORSen
dc.subjectPARIETAL PLEURAen
dc.subjectWATER CHANNELSen
dc.subjectPROTEINen
dc.subjectFIBULIN-4en
dc.subjectTRIP6en
dc.subjectDIFFERENTIATIONen
dc.subjectGenetics & Heredityen
dc.titleGene expression profile of aquaporin 1 and associated interactors in malignant pleural mesotheliomaen
dc.typejournalArticleen


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