Εμφάνιση απλής εγγραφής

dc.creatorIliopoulos, D.en
dc.creatorGkretsi, V.en
dc.creatorTsezou, A.en
dc.date.accessioned2015-11-23T10:30:21Z
dc.date.available2015-11-23T10:30:21Z
dc.date.issued2010
dc.identifier10.1586/epr.10.27
dc.identifier.issn1478-9450
dc.identifier.urihttp://hdl.handle.net/11615/28575
dc.description.abstractOsteoarthritis (OA) is characterized by irreversible destruction of the articular cartilage. OA affects more than 100 million individuals worldwide and has a major impact on patients' quality of life. The lack of effective therapy that prevents, inhibits or reverses the progress of OA often leaves only the option of surgical interventions. Thus, identification of the factors that contribute to OA pathogenesis is necessary for better understanding of OA pathobiology and discovery of effective therapies. Recent proteomic studies have been conducted to identify pathological mediators and biomarkers of OA, which have pinpointed novel pathways involved in cartilage degeneration. This article summarizes the recent findings, compares major techniques used in OA proteomics and discusses key proteins in OA and their potential use as therapeutic targets.en
dc.source.uri<Go to ISI>://WOS:000284438900017
dc.subjectcartilageen
dc.subjectchondrocytesen
dc.subjectinteractome networksen
dc.subjectosteoarthritisen
dc.subjectproteomics methodsen
dc.subjectHUMAN ARTICULAR-CARTILAGEen
dc.subjectDIFFERENTIALLY EXPRESSED PROTEINSen
dc.subjectRECEPTOR-GAMMA AGONISTen
dc.subjectIN-VITROen
dc.subjectRHEUMATOID-ARTHRITISen
dc.subjectFUNCTIONALen
dc.subjectGENOMICSen
dc.subjectACTIN CYTOSKELETONen
dc.subjectMASS-SPECTROMETRYen
dc.subjectGENE-EXPRESSIONen
dc.subjectSYNOVIAL-FLUIDen
dc.subjectBiochemical Research Methodsen
dc.titleProteomics of osteoarthritic chondrocytes and cartilageen
dc.typejournalArticleen


Αρχεία σε αυτό το τεκμήριο

ΑρχείαΜέγεθοςΤύποςΠροβολή

Δεν υπάρχουν αρχεία που να σχετίζονται με αυτό το τεκμήριο.

Αυτό το τεκμήριο εμφανίζεται στις ακόλουθες συλλογές

Εμφάνιση απλής εγγραφής