dc.creator | Ikonomidis, A. | en |
dc.creator | Spanakis, N. | en |
dc.creator | Poulou, A. | en |
dc.creator | Pournaras, S. | en |
dc.creator | Markou, F. | en |
dc.creator | Tsakris, A. | en |
dc.date.accessioned | 2015-11-23T10:30:19Z | |
dc.date.available | 2015-11-23T10:30:19Z | |
dc.date.issued | 2007 | |
dc.identifier | 10.1089/mdr.2007.768 | |
dc.identifier.issn | 1076-6294 | |
dc.identifier.uri | http://hdl.handle.net/11615/28562 | |
dc.description.abstract | Enterobacter cloacae strains are still infrequently resistant to carbapenems. A carbapenem-resistant clinical isolate of E. cloacae producing a plasmid-mediated metallo-beta-lactamase (MBL), VIM-4, was recovered from a Greek hospitalized patient. The bla(VIM-4) gene was located in the variable array of a class 1 integron structure repeatedly detected among bla(VIM-1)-bearing Gram-negative pathogens in Greece. The isolate possessed also on the same conjugative plasmid an extended-spectrum beta-lactamase (ESBL), SHV-2a, which contributed to the beta-lactam-resistant phenotype. This is the first report showing co-transfer of an ESBL with a VIM-type MBL. It suggests also that different VIM-type gene cassettes have been incorporated in a common integron structure, which seems indigenous of Gram-negative pathogens in our region. | en |
dc.source | Microbial Drug Resistance-Mechanisms Epidemiology and Disease | en |
dc.source.uri | <Go to ISI>://WOS:000252297200001 | |
dc.subject | KLEBSIELLA-PNEUMONIAE | en |
dc.subject | PSEUDOMONAS-AERUGINOSA | en |
dc.subject | ESCHERICHIA-COLI | en |
dc.subject | ACINETOBACTER-BAUMANNII | en |
dc.subject | MOLECULAR EPIDEMIOLOGY | en |
dc.subject | 1ST IDENTIFICATION | en |
dc.subject | GREEK HOSPITALS | en |
dc.subject | GENE | en |
dc.subject | OUTBREAK | en |
dc.subject | BLA(VIM-1) | en |
dc.subject | Infectious Diseases | en |
dc.subject | Microbiology | en |
dc.subject | Pharmacology & Pharmacy | en |
dc.title | Emergence of carbapenem-resistant enterobacter cloacae carrying VIM-4 metallo-beta-lactamase and SHV-2a extended-spectrum beta-lactamase in a conjugative plasmid | en |
dc.type | journalArticle | en |