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Natural products and their derivatives as inhibitors of glycogen phosphorylase: potential treatment for type 2 diabetes
dc.creator | Hayes, J. M. | en |
dc.creator | Kantsadi, A. L. | en |
dc.creator | Leonidas, D. D. | en |
dc.date.accessioned | 2015-11-23T10:30:05Z | |
dc.date.available | 2015-11-23T10:30:05Z | |
dc.date.issued | 2014 | |
dc.identifier | 10.1007/s11101-014-9360-6 | |
dc.identifier.issn | 1568-7767 | |
dc.identifier.uri | http://hdl.handle.net/11615/28484 | |
dc.description.abstract | Glycogen phosphorylase (GP) (EC 2.4.1.1) is an important therapeutic target for the potential treatment of type 2 diabetes. The search for potent, selective and drug-like GP inhibitors which may eventually lead to hypoglycaemic agents has to date uncovered a number of natural product inhibitors with both pharmaceutical and nutraceutical potential. GP is an allosteric protein with at least six different ligand binding sites that modulate its enzymatic activity. Hence, inhibitors with considerable structural diversity can be designed. This review is focused on advances in the discovery of natural products and their derivatives as GP inhibitors. | en |
dc.source.uri | <Go to ISI>://WOS:000336390100008 | |
dc.subject | Diabetes | en |
dc.subject | Flavonoids | en |
dc.subject | Glucose analogues | en |
dc.subject | Indirubins | en |
dc.subject | Pentacyclic | en |
dc.subject | triterpenes | en |
dc.subject | GLUCOSE ANALOG INHIBITORS | en |
dc.subject | OLEANOLIC ACID-DERIVATIVES | en |
dc.subject | IN-VITRO | en |
dc.subject | INHIBITION | en |
dc.subject | BIOLOGICAL EVALUATION | en |
dc.subject | PENTACYCLIC TRITERPENES | en |
dc.subject | STRUCTURAL | en |
dc.subject | BASIS | en |
dc.subject | ANTIDIABETIC AGENTS | en |
dc.subject | DEGRADING ENZYMES | en |
dc.subject | CRYSTAL-STRUCTURE | en |
dc.subject | ALLOSTERIC SITE | en |
dc.subject | Plant Sciences | en |
dc.title | Natural products and their derivatives as inhibitors of glycogen phosphorylase: potential treatment for type 2 diabetes | en |
dc.type | journalArticle | en |
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