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Impact of heptavalent pneumococcal conjugate vaccine on nasopharyngeal carriage of penicillin-resistant Streptococcus pneumonide among day-care center attendees in central Greece
dc.creator | Grivea, I. N. | en |
dc.creator | Panagiotou, M. | en |
dc.creator | Tsantouli, A. G. | en |
dc.creator | Syrogiannopoulos, G. A. | en |
dc.date.accessioned | 2015-11-23T10:29:15Z | |
dc.date.available | 2015-11-23T10:29:15Z | |
dc.date.issued | 2008 | |
dc.identifier | 10.1097/INF.0b013e318168d28a | |
dc.identifier.issn | 0891-3668 | |
dc.identifier.uri | http://hdl.handle.net/11615/28234 | |
dc.description.abstract | Background: In Greece, the heptavalent pneumococcal conjugate vaccine (PCV7) became available in October 2004 and it was incorporated into the national immunization schedule in January 2006. Methods: In February 2005, a yearly surveillance of the nasopharyngeal colonization with Streptococcus pneumoniae in children attending day-care centers in Central Greece began. Results: Between February 2005 and May 2007, nasopharyngeal cultures were obtained from 1829 children aged 13-76 months (median age, 47 months). The proportion of attendees vaccinated with >= 1 doses of PCV7 increased from 13% (2005) to 33% (2006) and to 70% (2007); 98% had been immunized on toddler catch-up schedules. Among vaccinated carriers, the proportion of PCV7 serotypes decreased from 33% (2005) to 29% (2006) and to 8.6% (2007) (chi(2) for trend, P < 0.001), the proportion of PCV7-related serotypes increased from 13% (2005) to 26% (2006) and to 28% (2007) (P = 0.16), whereas the proportion of non-PCV7 serotypes was 48% in 2005, 31% in 2006, and 55% in 2007 (P = 0.17). The proportion of PCV7 serotypes declined also among unvaccinated carriers. The carriage of serotype 19A did not increase. Among vaccinated carriers, the rate of highly penicillin-resistant isolates decreased from year I to year 3, respectively, 11%, 7.7%, and 0.6% (P = 0.001), whereas the proportion of penicillin-intermediate pneumococci was 13% in 2005, 23% in 2006, and 26% in 2007 (P = 0.22). Conclusions: In Central Greece, widespread PCV vaccination was followed by a significant reduction of carriage of highly penicillin-resistant pneumococci. The frequency of penicillin-intermediate isolates did not change significantly among vaccinated carriers. | en |
dc.source | Pediatric Infectious Disease Journal | en |
dc.source.uri | <Go to ISI>://WOS:000256606500007 | |
dc.subject | Streptococcus pneiumoniae | en |
dc.subject | heptavalent pneumococcal conjugate vaccine | en |
dc.subject | ANTIMICROBIAL RESISTANCE | en |
dc.subject | SEROTYPE DISTRIBUTION | en |
dc.subject | ANTIBIOTIC USE | en |
dc.subject | OTITIS-MEDIA | en |
dc.subject | CHILDREN | en |
dc.subject | DISEASE | en |
dc.subject | COLONIZATION | en |
dc.subject | REDUCTION | en |
dc.subject | INFANTS | en |
dc.subject | LIFE | en |
dc.subject | Immunology | en |
dc.subject | Infectious Diseases | en |
dc.subject | Pediatrics | en |
dc.title | Impact of heptavalent pneumococcal conjugate vaccine on nasopharyngeal carriage of penicillin-resistant Streptococcus pneumonide among day-care center attendees in central Greece | en |
dc.type | journalArticle | en |
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