Epithelium-dependent regulation of airways smooth muscle function. A histamine-nitric oxide pathway
dc.creator | Gourgoulianis, K. | en |
dc.creator | Iliodromitis, C. Z. | en |
dc.creator | Hatziefthimiou, A. | en |
dc.creator | Molyvdas, P. A. | en |
dc.date.accessioned | 2015-11-23T10:28:54Z | |
dc.date.available | 2015-11-23T10:28:54Z | |
dc.date.issued | 1998 | |
dc.identifier | 10.1080/09629359890785 | |
dc.identifier.issn | 9629351 | |
dc.identifier.uri | http://hdl.handle.net/11615/28121 | |
dc.description.abstract | The airway epithelium is responsible for the production of a number of arachidonic acid and non-prostanoid inhibitory factors. Epithelium synthesizes nitric oxide (NO) which may be important in regulating the function of airways smooth muscles. We studied in vitro the effect of histamine (100 nM-100 μM) which increases the NO release on rabbit airway smooth muscles induced by 80 mM KCl in the presence or not of 10-5 Methylene blue (MB) (inactivator of guanylate cyclase) or N(G)-monomethyl L- arginine (L-NMMA), a NOS inhibitor. All experiments were done in tracheal muscle strips from 28 rabbits with epithelium and after epithelium removal. The additional use of histamine (1 μM) on KCl contraction induced a relaxation of 10% of the initial contraction. The additional use of L-NMMA decreased the relaxation to 5% of initial contraction. MB rather than L-NMMA increased the contraction significantly (p<0.01). Epithelium removal increased the contraction induced by KCl (80 mM) and histamine (1 μM) by about 30% (p<0.001). NO release especially from epithelium regulates the airways smooth muscle functions. Damage to the epithelium may contribute to an increase in airways sensitivity, observed in asthma. | en |
dc.source.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-0032439928&partnerID=40&md5=484528557a5a93d6ba2f11c180571b70 | |
dc.subject | Bronchial asthma | en |
dc.subject | Epithelium | en |
dc.subject | Histamine | en |
dc.subject | Nitric oxide | en |
dc.subject | methylene blue | en |
dc.subject | n(g) methylarginine | en |
dc.subject | animal tissue | en |
dc.subject | article | en |
dc.subject | asthma | en |
dc.subject | breathing muscle | en |
dc.subject | controlled study | en |
dc.subject | inflammation | en |
dc.subject | nonhuman | en |
dc.subject | priority journal | en |
dc.subject | rabbit | en |
dc.subject | smooth muscle | en |
dc.subject | trachea injury | en |
dc.subject | trachea mucosa | en |
dc.subject | trachea muscle | en |
dc.subject | Animals | en |
dc.subject | Enzyme Inhibitors | en |
dc.subject | Muscle, Smooth, Vascular | en |
dc.subject | omega-N-Methylarginine | en |
dc.subject | Rabbits | en |
dc.subject | Trachea | en |
dc.subject | Animalia | en |
dc.subject | Oryctolagus cuniculus | en |
dc.title | Epithelium-dependent regulation of airways smooth muscle function. A histamine-nitric oxide pathway | en |
dc.type | journalArticle | en |
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