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Elimination of Ras Suppressor-1 from Hepatocellular Carcinoma Cells Hinders their In Vitro Metastatic Properties
dc.creator | Gkretsi, V. | en |
dc.creator | Bogdanos, D. P. | en |
dc.date.accessioned | 2015-11-23T10:28:31Z | |
dc.date.available | 2015-11-23T10:28:31Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0250-7005 | |
dc.identifier.uri | http://hdl.handle.net/11615/28011 | |
dc.description.abstract | Background/Aim: Extracellular matrix (ECM) is of great significance for homeostasis in the liver. In fact, one of the stags leading to hepatocellular carcinoma (HCC) includes accumulation of excess ECM. Ras Suppressor-1 (RSU-1) is localized in the cell-ECM adhesions but its role in HCC is unexplored. Materials and Methods: We investigated the expression and role of RSU-1 in two HCC cell lines that differ in aggressiveness; non-invasive Alexander cells and highly invasive HepG2 cells. Results: Our results showed that RSU-1 expression is elevated in HepG2 cells both at the mRNA and protein level, while its silencing leads to increased cell proliferation in both cell lines. Interestingly, RSU-1 depletion from highly invasive HepG2 cells reduces cell adhesion and invasion. Conclusion: This is the first study to provide in vitro evidence for the involvement of RSU-1 in HCC cell invasive behavior. | en |
dc.source | Anticancer Research | en |
dc.source.uri | <Go to ISI>://WOS:000352462900036 | |
dc.subject | Hepatocellular carcinoma | en |
dc.subject | Ras suppressor-1 | en |
dc.subject | invasion | en |
dc.subject | adhesion | en |
dc.subject | MIGRATION | en |
dc.subject | BINDING | en |
dc.subject | LIVER | en |
dc.subject | Oncology | en |
dc.title | Elimination of Ras Suppressor-1 from Hepatocellular Carcinoma Cells Hinders their In Vitro Metastatic Properties | en |
dc.type | journalArticle | en |
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