dc.creator | Giannoukas, A. D. | en |
dc.creator | Paraskevas, K. I. | en |
dc.creator | Koutsias, S. | en |
dc.creator | Argyriou, C. | en |
dc.creator | Saleptsis, V. | en |
dc.creator | Palombo, D. | en |
dc.date.accessioned | 2015-11-23T10:28:11Z | |
dc.date.available | 2015-11-23T10:28:11Z | |
dc.date.issued | 2014 | |
dc.identifier | 10.1177/0003319713499816 | |
dc.identifier.issn | 0003-3197 | |
dc.identifier.uri | http://hdl.handle.net/11615/27929 | |
dc.description.abstract | We investigated the role of oral vitamin K antagonists (VKAs) in graft patency, limb salvage, major and minor bleeding rates in patients undergoing infrainguinal bypass surgery. Five randomized-controlled trials (RCTs; n = 3746 patients) comparing VKA versus non-VKA treatment outcomes in patients undergoing infrainguinal bypass surgery were analyzed. The VKA treatment was associated with improved graft patency rates when a vein graft was used (risk ratio [RR]: 0.74; P = .0004), while there was no difference with prosthetic grafts (RR: 1.07; P = .39). The VKA treatment was also associated with improved limb salvage rates (RR: 0.33; P = .0008). Major and minor bleeding complications were higher in the VKA group. In conclusion, VKA treatment is associated with improved graft patency and limb salvage rates when a vein graft is used at the price of an increased risk of bleeding. Due to the inconsistent results, further well-designed RCTs are needed. | en |
dc.source.uri | <Go to ISI>://WOS:000340112100004 | |
dc.subject | coumadin | en |
dc.subject | warfarin | en |
dc.subject | vitamin K antagonists | en |
dc.subject | antiplatelet agents | en |
dc.subject | peripheral arterial disease | en |
dc.subject | infrainguinal bypass | en |
dc.subject | graft patency | en |
dc.subject | SAPHENOUS-VEIN | en |
dc.subject | FEMOROPOPLITEAL BYPASS | en |
dc.subject | VASCULAR-SURGERY | en |
dc.subject | POLYTETRAFLUOROETHYLENE GRAFTS | en |
dc.subject | ANTICOAGULANT TREATMENT | en |
dc.subject | RANDOMIZED-TRIAL | en |
dc.subject | ASPIRIN | en |
dc.subject | LONG | en |
dc.subject | EXPRESSION | en |
dc.subject | MORBIDITY | en |
dc.subject | Peripheral Vascular Disease | en |
dc.title | The Role of Oral Vitamin K Antagonists in the Outcome of Infrainguinal Bypass Procedures | en |
dc.type | journalArticle | en |