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Regulated expression of the Saccharomyces cerevisiae Fre1p/Fre2p Fe/Cu reductase related genes

dc.creatorGeorgatsou, E.en
dc.creatorAlexandraki, D.en
dc.date.accessioned2015-11-23T10:27:32Z
dc.date.available2015-11-23T10:27:32Z
dc.date.issued1999
dc.identifier10.1002/(SICI)1097-0061(199905)15:7<573
dc.identifier.issn0749503X
dc.identifier.urihttp://hdl.handle.net/11615/27735
dc.description.abstractThe Saccharomyces cerevisiae genome contains nine open reading frames (ORFs) - YLR214w (FRE1), YKL220c (FRE2), YOR381w, YNR060w, YOR384w, YLL051c, YOL152w, YGL160w and YLR047c - which, based on amino acid sequence similarity, fall in the category of iron/copper reductase-related genes. FRE1 and FRE2 are the first identified and studied genes of this family. They both encode for plasma membrane ferric/cupric reductases and their expression is regulated by iron and copper availability, mediated by the transcription factors Aft1p and Mac1p, respectively. We have studied the expression of the seven ORFs of unknown function by monitoring mRNA accumulation under different growth conditions, namely, their response to iron and copper availability in the medium, as well as the involvement of transcription factors Aft1p and Mac1p in their expression. A compilation of these results, together with sequence comparison data, permits a first classification of these genes under three major groups: genes mainly regulated by iron availability, genes mainly regulated by copper availability and genes not regulated by either metal.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-0032898494&partnerID=40&md5=fce4e4d161762a32121f4159dec36aef
dc.subjectFerric/cupric reductasesen
dc.subjectIron/copper homeostasisen
dc.subjectMetalloregulationen
dc.subjectMultigene familiesen
dc.subjectcopperen
dc.subjectironen
dc.subjectmessenger RNAen
dc.subjectoxidoreductaseen
dc.subjecttranscription factoren
dc.subjectarticleen
dc.subjectcontrolled studyen
dc.subjectfungal geneticsen
dc.subjectgene expression regulationen
dc.subjectnonhumanen
dc.subjectopen reading frameen
dc.subjectpriority journalen
dc.subjectsaccharomyces cerevisiaeen
dc.subjectDNA, Fungalen
dc.subjectFMN Reductaseen
dc.subjectFungal Proteinsen
dc.subjectGene Expression Regulation, Fungalen
dc.subjectNADH, NADPH Oxidoreductasesen
dc.subjectNuclear Proteinsen
dc.subjectNucleic Acid Hybridizationen
dc.subjectOpen Reading Framesen
dc.subjectPromoter Regions (Genetics)en
dc.subjectRNA, Fungalen
dc.subjectRNA, Messengeren
dc.subjectSaccharomyces cerevisiae Proteinsen
dc.subjectSequence Analysis, DNAen
dc.subjectTranscription Factorsen
dc.titleRegulated expression of the Saccharomyces cerevisiae Fre1p/Fre2p Fe/Cu reductase related genesen
dc.typejournalArticleen


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