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Seven new loci associated with age-related macular degeneration

dc.creatorFritsche, L. G.en
dc.creatorChen, W.en
dc.creatorSchu, M.en
dc.creatorYaspan, B. L.en
dc.creatorYu, Y.en
dc.creatorThorleifsson, G.en
dc.creatorZack, D. J.en
dc.creatorArakawa, S.en
dc.creatorCipriani, V.en
dc.creatorRipke, S.en
dc.creatorIgo, R. P.en
dc.creatorBuitendijk, G. H. S.en
dc.creatorSim, X.en
dc.creatorWeeks, D. E.en
dc.creatorGuymer, R. H.en
dc.creatorMerriam, J. E.en
dc.creatorFrancis, P. J.en
dc.creatorHannum, G.en
dc.creatorAgarwal, A.en
dc.creatorArmbrecht, A. M.en
dc.creatorAudo, I.en
dc.creatorAung, T.en
dc.creatorBarile, G. R.en
dc.creatorBenchaboune, M.en
dc.creatorBird, A. C.en
dc.creatorBishop, P. N.en
dc.creatorBranham, K. E.en
dc.creatorBrooks, M.en
dc.creatorBrucker, A. J.en
dc.creatorCade, W. H.en
dc.creatorCain, M. S.en
dc.creatorCampochiaro, P. A.en
dc.creatorChan, C. C.en
dc.creatorCheng, C. Y.en
dc.creatorChew, E. Y.en
dc.creatorChin, K. A.en
dc.creatorChowers, I.en
dc.creatorClayton, D. G.en
dc.creatorCojocaru, R.en
dc.creatorConley, Y. P.en
dc.creatorCornes, B. K.en
dc.creatorDaly, M. J.en
dc.creatorDhillon, B.en
dc.creatorEdwards, A. O.en
dc.creatorEvangelou, E.en
dc.creatorFagerness, J.en
dc.creatorFerreyra, H. A.en
dc.creatorFriedman, J. S.en
dc.creatorGeirsdottir, A.en
dc.creatorGeorge, R. J.en
dc.creatorGieger, C.en
dc.creatorGupta, N.en
dc.creatorHagstrom, S. A.en
dc.creatorHarding, S. P.en
dc.creatorHaritoglou, C.en
dc.creatorHeckenlively, J. R.en
dc.creatorHolz, F. G.en
dc.creatorHughes, G.en
dc.creatorIoannidis, J. P. A.en
dc.creatorIshibashi, T.en
dc.creatorJoseph, P.en
dc.creatorJun, G.en
dc.creatorKamatani, Y.en
dc.creatorKatsanis, N.en
dc.creatorN Keilhauer, C.en
dc.creatorKhan, J. C.en
dc.creatorKim, I. K.en
dc.creatorKiyohara, Y.en
dc.creatorKlein, B. E. K.en
dc.creatorKlein, R.en
dc.creatorKovach, J. L.en
dc.creatorKozak, I.en
dc.creatorLee, C. J.en
dc.creatorLee, K. E.en
dc.creatorLichtner, P.en
dc.creatorLotery, A. J.en
dc.creatorMeitinger, T.en
dc.creatorMitchell, P.en
dc.creatorMohand-Saïd, S.en
dc.creatorMoore, A. T.en
dc.creatorMorgan, D. J.en
dc.creatorMorrison, M. A.en
dc.creatorMyers, C. E.en
dc.creatorNaj, A. C.en
dc.creatorNakamura, Y.en
dc.creatorOkada, Y.en
dc.creatorOrlin, A.en
dc.creatorOrtube, M. C.en
dc.creatorOthman, M. I.en
dc.creatorPappas, C.en
dc.creatorPark, K. H.en
dc.creatorPauer, G. J. T.en
dc.creatorPeachey, N. S.en
dc.creatorPoch, O.en
dc.creatorPriya, R. R.en
dc.creatorReynolds, R.en
dc.creatorRichardson, A. J.en
dc.creatorRipp, R.en
dc.creatorRudolph, G.en
dc.creatorRyu, E.en
dc.creatorSahel, J. A.en
dc.creatorSchaumberg, D. A.en
dc.creatorScholl, H. P. N.en
dc.creatorSchwartz, S. G.en
dc.creatorScott, W. K.en
dc.creatorShahid, H.en
dc.creatorSigurdsson, H.en
dc.creatorSilvestri, G.en
dc.creatorSivakumaran, T. A.en
dc.creatorSmith, R. T.en
dc.creatorSobrin, L.en
dc.creatorSouied, E. H.en
dc.creatorStambolian, D. E.en
dc.creatorStefansson, H.en
dc.creatorSturgill-Short, G. M.en
dc.creatorTakahashi, A.en
dc.creatorTosakulwong, N.en
dc.creatorTruitt, B. J.en
dc.creatorTsironi, E. E.en
dc.creatorUitterlinden, A. G.en
dc.creatorVan Duijn, C. M.en
dc.creatorVijaya, L.en
dc.creatorVingerling, J. R.en
dc.creatorVithana, E. N.en
dc.creatorWebster, A. R.en
dc.creatorWichmann, H. E.en
dc.creatorWinkler, T. W.en
dc.creatorWong, T. Y.en
dc.creatorWright, A. F.en
dc.creatorZelenika, D.en
dc.creatorZhang, M.en
dc.creatorZhao, L.en
dc.creatorZhang, K.en
dc.creatorKlein, M. L.en
dc.creatorHageman, G. S.en
dc.creatorLathrop, G. M.en
dc.creatorStefansson, K.en
dc.creatorAllikmets, R.en
dc.creatorBaird, P. N.en
dc.creatorGorin, M. B.en
dc.creatorWang, J. J.en
dc.creatorKlaver, C. C. W.en
dc.creatorSeddon, J. M.en
dc.creatorPericak-Vance, M. A.en
dc.creatorIyengar, S. K.en
dc.creatorYates, J. R. W.en
dc.creatorSwaroop, A.en
dc.creatorWeber, B. H. F.en
dc.creatorKubo, M.en
dc.creatorDeangelis, M. M.en
dc.creatorLéveillard, T.en
dc.creatorThorsteinsdottir, U.en
dc.creatorHaines, J. L.en
dc.creatorFarrer, L. A.en
dc.creatorHeid, I. M.en
dc.creatorAbecasis, G. R.en
dc.date.accessioned2015-11-23T10:26:47Z
dc.date.available2015-11-23T10:26:47Z
dc.date.issued2013
dc.identifier10.1038/ng.2578
dc.identifier.issn10614036
dc.identifier.urihttp://hdl.handle.net/11615/27576
dc.description.abstractAge-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate the understanding of AMD biology and help design new therapies, we executed a collaborative genome-wide association study, including >17,100 advanced AMD cases and >60,000 controls of European and Asian ancestry. We identified 19 loci associated at P < 5 × 10 -8. These loci show enrichment for genes involved in the regulation of complement activity, lipid metabolism, extracellular matrix remodeling and angiogenesis. Our results include seven loci with associations reaching P < 5 × 10-8 for the first time, near the genes COL8A1-FILIP1L, IER3-DDR1, SLC16A8, TGFBR1, RAD51B, ADAMTS9 and B3GALTL. A genetic risk score combining SNP genotypes from all loci showed similar ability to distinguish cases and controls in all samples examined. Our findings provide new directions for biological, genetic and therapeutic studies of AMD.en
dc.sourceNature Geneticsen
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84875706378&partnerID=40&md5=e0203b979643081dc774c59da5b5aa21
dc.subjectmonocarboxylate transporter 3en
dc.subjecttransforming growth factor beta1en
dc.subjectadolescenten
dc.subjectadulten
dc.subjectageden
dc.subjectangiogenesisen
dc.subjectarticleen
dc.subjectcomplement systemen
dc.subjectcontrolled studyen
dc.subjectcopy number variationen
dc.subjectextracellular matrixen
dc.subjectgene clusteren
dc.subjectgene controlen
dc.subjectgene expressionen
dc.subjectgene linkage disequilibriumen
dc.subjectgene locusen
dc.subjectgenetic associationen
dc.subjectgenetic risken
dc.subjectgeographic atrophyen
dc.subjecthumanen
dc.subjectlipid metabolismen
dc.subjectmajor clinical studyen
dc.subjectmeta analysis (topic)en
dc.subjectpriority journalen
dc.subjectretina macula age related degenerationen
dc.subjectBiological Markersen
dc.subjectCase-Control Studiesen
dc.subjectFemaleen
dc.subjectGenetic Locien
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectGenome-Wide Association Studyen
dc.subjectHumansen
dc.subjectMacular Degenerationen
dc.subjectMaleen
dc.subjectMeta-Analysis as Topicen
dc.subjectPolymorphism, Single Nucleotideen
dc.subjectRisk Factorsen
dc.titleSeven new loci associated with age-related macular degenerationen
dc.typejournalArticleen


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