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Loss of heterozygosity in DNA mismatch repair genes in human atherosclerotic plaques

dc.creatorFlouris, G. A.en
dc.creatorArvanitis, D. A.en
dc.creatorParissis, J. T.en
dc.creatorArvanitis, D. L.en
dc.creatorSpandidos, D. A.en
dc.date.accessioned2015-11-23T10:26:38Z
dc.date.available2015-11-23T10:26:38Z
dc.date.issued2001
dc.identifier10.1006/mcbr.2000.0255
dc.identifier.issn15224724
dc.identifier.urihttp://hdl.handle.net/11615/27506
dc.description.abstractTo detect the incidence of loss of heterozygosity (LOH) in DNA mismatch repair genes (MMR) occurring in atherosclerosis, fifty human autopsy cases of atherosclerosis were examined for LOH using 19 microsatellite markers, in three single and four tetraplex microsatellite assays. The markers used are located on or close to MMR genes. Fourteen specimens (28%) showed allelic imbalance in at least one locus. Loci hMSH2 (2p22.3-p16.1), hPMS1 (2q24.1-q32.1), and hMLH1 (3p21.32-p21.1) exhibited LOH (10, 10, and 12% respectively). We found that loss of heterozygosity on hMSH2, hPMS1, and hMLH1, occurs in atherosclerosis. The occurrence of such genomic alterations may represent important events in the development of atherosclerosis. © 2000 Academic Press.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-0035166126&partnerID=40&md5=19d9f2b9b1d82efe672c550ed028cdc9
dc.subjectAtherosclerosisen
dc.subjectCoronary diseaseen
dc.subjectEnzyme (kinetics)en
dc.subjectGenetic codeen
dc.subjectSequence (DNA/RNA/prot)en
dc.subjectmicrosatellite DNAen
dc.subjectadulten
dc.subjectageden
dc.subjectalleleen
dc.subjectarticleen
dc.subjectassayen
dc.subjectatherosclerotic plaqueen
dc.subjectbase mispairingen
dc.subjectDNA modificationen
dc.subjectDNA repairen
dc.subjectfemaleen
dc.subjectgene locationen
dc.subjectgene locusen
dc.subjectgenomeen
dc.subjectheterozygosity lossen
dc.subjecthumanen
dc.subjecthuman tissueen
dc.subjectmaleen
dc.subjectmarker geneen
dc.subjectpriority journalen
dc.subjectArteriosclerosisen
dc.subjectChromosome Mappingen
dc.subjectChromosomes, Human, Pair 2en
dc.subjectChromosomes, Human, Pair 3en
dc.subjectHumansen
dc.subjectLoss of Heterozygosityen
dc.subjectMiddle Ageden
dc.subjectNucleic Acid Heteroduplexesen
dc.subjectPolymerase Chain Reactionen
dc.titleLoss of heterozygosity in DNA mismatch repair genes in human atherosclerotic plaquesen
dc.typejournalArticleen


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