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Effect of single dose irradiation on human glioblastoma spheroids in vitro

dc.creatorFehlauer, F.en
dc.creatorStalpers, L. J. A.en
dc.creatorPanayiotides, J.en
dc.creatorKaaijk, P.en
dc.creatorGonzález Gonźalez, D.en
dc.creatorLeenstra, S.en
dc.creatorVan Der Valk, P.en
dc.creatorSminia, P.en
dc.date.accessioned2015-11-23T10:26:30Z
dc.date.available2015-11-23T10:26:30Z
dc.date.issued2004
dc.identifier.issn1021335X
dc.identifier.urihttp://hdl.handle.net/11615/27434
dc.description.abstractInvestigation of the predictive value of a radiosurgery-relevant treatment of glioblastoma spheroids. Organotypic multicellular spheroids were cultured and irradiated (20 Gy). Morphology, apoptosis and immunohistochemical expression of p53, p21, MIB-1, TGF-β and VEGF were examined 4 h, 24 h, 7 days, and 14 days following treatment. Cell proliferation decreased, while apoptosis was increased. No morphological damage was observed. p53 expression was significantly increased after 4 h. TGF-β and VEGF expression were only slightly altered. Particularly early changes in proliferation and apoptosis can be observed in spheroids. Individual response differences suggest spheroids of human gliomas to be useful for monitoring radiosurgery effects.en
dc.sourceOncology Reportsen
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-3242755230&partnerID=40&md5=edcf33392066267b3cd2c9bc07f209fb
dc.subjectGliomaen
dc.subjectHistologyen
dc.subjectIrradiationen
dc.subjectRadiosurgeryen
dc.subjectSpheroidsen
dc.subjectprotein p53en
dc.subjecttransforming growth factor betaen
dc.subjecttumor markeren
dc.subjectvasculotropin Aen
dc.subjectarticleen
dc.subjectbrain tumoren
dc.subjectglioblastomaen
dc.subjecthumanen
dc.subjectmethodologyen
dc.subjectmortalityen
dc.subjectorgan culture techniqueen
dc.subjectpathologyen
dc.subjectprediction and forecastingen
dc.subjectradiotherapyen
dc.subjectsurvivalen
dc.subjectBrain Neoplasmsen
dc.subjectHumansen
dc.subjectOrgan Culture Techniquesen
dc.subjectPredictive Value of Testsen
dc.subjectSurvival Analysisen
dc.subjectTumor Markers, Biologicalen
dc.subjectTumor Suppressor Protein p53en
dc.subjectVascular Endothelial Growth Factor Aen
dc.titleEffect of single dose irradiation on human glioblastoma spheroids in vitroen
dc.typejournalArticleen


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