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New short route to unsaturated fluoroketonucleosides: Case of 5-fluoro-1-(6-0-acetyl-3,4-di-deoxy-3-fluoro-β-D-glycero-hex-3-eno-pyranos- 2-ulosyl) uracil

dc.creatorEgron, M. J.en
dc.creatorKomiotis, D.en
dc.creatorDorange, I.en
dc.creatorHerscovici, J.en
dc.creatorOllapally, A. P.en
dc.creatorAntonakis, K.en
dc.date.accessioned2015-11-23T10:26:05Z
dc.date.available2015-11-23T10:26:05Z
dc.date.issued2005
dc.identifier10.1081/NCN-59683
dc.identifier.issn15257770
dc.identifier.urihttp://hdl.handle.net/11615/27295
dc.description.abstractThe proposed short synthesis involves two key steps: Oxidation of the isopropylidene derivative of the 3-fluoronucleoside possessing a free hydroxyl group in 2-position and acetylation of deprotected 3-fluoro-2-ketonucleoside which, after a β-elimination reaction, gives the desired unsaturated ketonucleoside 5. Copyright © Taylor & Francis, Inc.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-22044448379&partnerID=40&md5=ac121ffefe37f698b8c090964e707674
dc.subject5 fluoro 1 (6 o acetyl 3,4 dideoxy 3 fluoro beta dextro glycerohex 3 enopyranos 2 ulosyl)uracilen
dc.subjectacetic acid derivativeen
dc.subjectfluorine derivativeen
dc.subjecthydroxyl groupen
dc.subjectketone derivativeen
dc.subjectnucleoside derivativeen
dc.subjectunclassified drugen
dc.subjecturacil derivativeen
dc.subjectacetylationen
dc.subjectarticleen
dc.subjectdeprotection reactionen
dc.subjectdrug synthesisen
dc.subjectelimination reactionen
dc.subjectoxidationen
dc.subjectreaction analysisen
dc.subjectChromatography, Thin Layeren
dc.subjectFluorineen
dc.subjectFluorouracilen
dc.subjectImmunosuppressive Agentsen
dc.subjectKetonesen
dc.subjectMagnetic Resonance Spectroscopyen
dc.subjectModels, Chemicalen
dc.subjectNucleosidesen
dc.subjectUracilen
dc.titleNew short route to unsaturated fluoroketonucleosides: Case of 5-fluoro-1-(6-0-acetyl-3,4-di-deoxy-3-fluoro-β-D-glycero-hex-3-eno-pyranos- 2-ulosyl) uracilen
dc.typejournalArticleen


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