Fc gamma receptor polymorphisms and their association with periodontal disease: a meta-analysis
dc.creator | Dimou, N. L. | en |
dc.creator | Nikolopoulos, G. K. | en |
dc.creator | Hamodrakas, S. J. | en |
dc.creator | Bagos, P. G. | en |
dc.date.accessioned | 2015-11-23T10:25:44Z | |
dc.date.available | 2015-11-23T10:25:44Z | |
dc.date.issued | 2010 | |
dc.identifier | 10.1111/j.1600-051X.2009.01530.x | |
dc.identifier.issn | 0303-6979 | |
dc.identifier.uri | http://hdl.handle.net/11615/27125 | |
dc.description.abstract | Aim: A systematic review and a meta-analysis were conducted in order to investigate the potential association of Fc gamma receptor (Fc gamma R) polymorphisms with susceptibility to aggressive and chronic periodontal disease. Materials and Methods: A database search yielded a total of 17 studies involving 1685 cases and 1570 controls. Three polymorphisms were included in the meta-analysis: Fc gamma RIIA H131R (rs1801274), Fc gamma RIIIA F158V (rs396991) and Fc gamma RIIIB NA1/NA2. Random-effect models were used in the analysis. Odds ratios (ORs) along with their 95% confidence intervals (CIs) were computed to compare the distribution of alleles and genotypes between cases and controls. Results and Conclusions: The Fc gamma RIIIB NA1/NA2 polymorphism was associated with both aggressive (per-allele OR 2.005, 95% CI: 1.044, 3.851) and chronic periodontitis (recessive contrast NA2NA2 versus NA1NA1+NA1NA2 OR 1.397, 95% CI: 1.039, 1.878). The analysis showed weak evidence for association between the Fc gamma RIIA H131R polymorphism and aggressive periodontitis in Asians (R versus H allele OR 1.579, 95% CI: 1.025, 2.432). On the contrary, no relationship was identified between Fc gamma RIIIA F158V and periodontal disease. Accumulating evidence from basic research makes the suggested association between Fc gamma RIIIB NA1/NA2 polymorphism and periodontitis biologically plausible. Further research, however, is needed in order to assess possible gene-gene or gene-environment interactions (i.e. with smoking). | en |
dc.source.uri | <Go to ISI>://WOS:000274200400006 | |
dc.subject | Fc gamma receptor | en |
dc.subject | meta-analysis | en |
dc.subject | periodontitis | en |
dc.subject | polymorphism | en |
dc.subject | GINGIVAL CREVICULAR NEUTROPHILS | en |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | en |
dc.subject | EARLY-ONSET PERIODONTITIS | en |
dc.subject | ADULT PERIODONTITIS | en |
dc.subject | AGGRESSIVE | en |
dc.subject | PERIODONTITIS | en |
dc.subject | JAPANESE PATIENTS | en |
dc.subject | GENE POLYMORPHISMS | en |
dc.subject | RISK-FACTORS | en |
dc.subject | PORPHYROMONAS-GINGIVALIS | en |
dc.subject | PERIPHERAL NEUTROPHILS | en |
dc.subject | Dentistry, Oral Surgery & Medicine | en |
dc.title | Fc gamma receptor polymorphisms and their association with periodontal disease: a meta-analysis | en |
dc.type | journalArticle | en |
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