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Complete genomic characterization of an intertypic Sabin 3/Sabin 2 capsid recombinant
dc.creator | Dedepsidis, E. | en |
dc.creator | Pliaka, V. | en |
dc.creator | Kyriakopoulou, Z. | en |
dc.creator | Brakoulias, C. | en |
dc.creator | Levidiotou-Stefanou, S. | en |
dc.creator | Pratti, A. | en |
dc.creator | Mamuris, Z. | en |
dc.creator | Markoulatos, P. | en |
dc.date.accessioned | 2015-11-23T10:25:16Z | |
dc.date.available | 2015-11-23T10:25:16Z | |
dc.date.issued | 2008 | |
dc.identifier | 10.1111/j.1574-695X.2008.00381.x | |
dc.identifier.issn | 0928-8244 | |
dc.identifier.uri | http://hdl.handle.net/11615/26956 | |
dc.description.abstract | The genetic properties of strain K/2002, isolated from fecal samples of a 7-month-old child who had received his first oral poliovirus vaccine (OPV) dose at the age of 3 months, are described. Preliminary sequencing characterization of isolate K/2002 revealed an S3/S2 recombination event at the 3' end of the VP1 coding region. A recombination event resulted in the introduction of six Sabin 2 amino acid residues in a Sabin 3 genomic background. Furthermore, mutations associated with loss of the attenuated phenotype of Sabin 3 strains have been identified in the genome of isolate K/2002. The data presented here emphasize the need for careful planning of vaccination strategies, which involve stopping OPV administration in regions that are certified to be polio-free. | en |
dc.source | Fems Immunology and Medical Microbiology | en |
dc.source.uri | <Go to ISI>://WOS:000253978900005 | |
dc.subject | poliovirus | en |
dc.subject | recombination | en |
dc.subject | capsid | en |
dc.subject | evolution | en |
dc.subject | VACCINE-DERIVED POLIOVIRUS | en |
dc.subject | IMMUNODEFICIENT PATIENT | en |
dc.subject | WILD POLIOVIRUS | en |
dc.subject | PARALYTIC POLIOMYELITIS | en |
dc.subject | 3-DIMENSIONAL STRUCTURE | en |
dc.subject | AMINO-TERMINUS | en |
dc.subject | EVOLUTION | en |
dc.subject | TYPE-1 | en |
dc.subject | RECEPTOR | en |
dc.subject | VP1 | en |
dc.subject | Immunology | en |
dc.subject | Infectious Diseases | en |
dc.subject | Microbiology | en |
dc.title | Complete genomic characterization of an intertypic Sabin 3/Sabin 2 capsid recombinant | en |
dc.type | journalArticle | en |
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