dc.creator | Dardiotis, E. | en |
dc.creator | Hadjigeorgiou, G. M. | en |
dc.creator | Dardioti, M. | en |
dc.creator | Scarmeas, N. | en |
dc.creator | Paterakis, K. | en |
dc.creator | Aggelakis, K. | en |
dc.creator | Komnos, A. | en |
dc.creator | Tasiou, A. | en |
dc.creator | Xiromerisiou, G. | en |
dc.creator | Gabranis, I. | en |
dc.creator | Zintzaras, E. | en |
dc.creator | Papadimitriou, A. | en |
dc.creator | Karantanas, A. | en |
dc.date.accessioned | 2015-11-23T10:25:12Z | |
dc.date.available | 2015-11-23T10:25:12Z | |
dc.date.issued | 2008 | |
dc.identifier | 10.1159/000121420 | |
dc.identifier.issn | 0014-3022 | |
dc.identifier.uri | http://hdl.handle.net/11615/26928 | |
dc.description.abstract | Background/Aims: Alpha-1 antichymotrypsin (ACT), a serine proteinase inhibitor, has been implicated in vascular pathology. The TT genotype of the ACT signal peptide A/T polymorphism has been reported to confer susceptibility to primary intracerebral hemorrhage (PICH). We conducted a prospective study to test possible association of ACT signal peptide A/T polymorphism with PICH in a Greek cohort with enough power (80%) to detect a twofold increase in the odds ratio. Methods: We prospectively recruited 147 patients with PICH. ACT signal peptide A/T genotypes were determined in patients and 206 healthy, age- and sex-matched control subjects from the neurology outpatient clinic using the polymerase chain reaction restriction fragment length polymorphism method. Results: Our study did not show an association between ACT signal peptide A/T polymorphism and PICH. We also failed to find any influence on age at onset, the location and volume of PICH as well as on clinical severity at admission or 6-month outcome. Conclusion: Our data failed to confirm an association between ACT signal peptide A/T polymorphism and PICH. However, we cannot exclude the possibility that the TT genotype confers susceptibility at less than a twofold increase. Copyright (c) 2008 S. Karger AG, Basel. | en |
dc.source | European Neurology | en |
dc.source.uri | <Go to ISI>://WOS:000254894300006 | |
dc.subject | intracerebral hemorrhage | en |
dc.subject | stroke | en |
dc.subject | alpha-1 antichymotrypsin | en |
dc.subject | ALZHEIMERS-DISEASE RISK | en |
dc.subject | ALPHA(1)-ANTICHYMOTRYPSIN POLYMORPHISM | en |
dc.subject | ALPHA-1-ANTICHYMOTRYPSIN POLYMORPHISM | en |
dc.subject | APOLIPOPROTEIN-E | en |
dc.subject | BRAIN-INJURY | en |
dc.subject | CATHEPSIN-G | en |
dc.subject | ASSOCIATION | en |
dc.subject | POPULATION | en |
dc.subject | SURVIVAL | en |
dc.subject | STROKE | en |
dc.subject | Clinical Neurology | en |
dc.subject | Neurosciences | en |
dc.title | Alpha-1 antichymotrypsin gene signal peptide A/T polymorphism and primary intracerebral hemorrhage | en |
dc.type | journalArticle | en |