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Retinoid receptor alpha and beta expression in serous ovarian tumors

dc.creatorDaponte, A.en
dc.creatorKostopoulou, E.en
dc.creatorChiotoglou, I.en
dc.creatorVanakara, P.en
dc.creatorMinas, M.en
dc.creatorNakou, M.en
dc.creatorKallitsaris, A.en
dc.creatorKollia, P.en
dc.creatorKoukoulis, G.en
dc.creatorMessinis, I. E.en
dc.date.accessioned2015-11-23T10:25:09Z
dc.date.available2015-11-23T10:25:09Z
dc.date.issued2007
dc.identifier10.1159/000120633
dc.identifier.issn0030-2414
dc.identifier.urihttp://hdl.handle.net/11615/26899
dc.description.abstractThe expression of retinoid acid receptors alpha (RAR alpha) and beta (RAR beta) and estrogen receptor alpha (ER alpha) was assessed by immunohistochemistry and Western blotting in normal ovaries, serous cystadenoma (n = 20), serous borderline (n = 14), and serous ovarian cancer (n = 47) and was correlated in cancer cases with stage, grade, progress-free survival (PFS), and survival. RAR alpha was increasingly expressed in benign cystadenomas, borderline, and low-stage and advanced-stage neoplasms (p < 0.001). In stage III, G3 serous carcinoma, increased RAR alpha expression was an independent prognostic factor associated with lower chemoresponse to first-line chemotherapy (taxol and carboplatin) and shorter PFS (p < 0.002). RAR beta and ER alpha expression did not correlate with RAR alpha tumor characteristics or PFS and survival. Copyright (C) 2008 S. Karger AG, Basel.en
dc.sourceOncologyen
dc.source.uri<Go to ISI>://WOS:000254740600013
dc.subjectretinoid receptor-alphaen
dc.subjectretinoid receptor-betaen
dc.subjectestrogenen
dc.subjectreceptor-alphaen
dc.subjectchemoresistanceen
dc.subjectprognostic factoren
dc.subjectimmunohistochemistryen
dc.subjectWestern bloten
dc.subjectserous ovarian canceren
dc.subjectBREAST-CANCER-CELLSen
dc.subjectESTROGEN-RECEPTORen
dc.subjectINDUCED APOPTOSISen
dc.subjectCARCINOMAen
dc.subjectCELLSen
dc.subjectACID RECEPTORSen
dc.subjectNECK-CANCERen
dc.subjectX-RECEPTORSen
dc.subjectHUMAN SKINen
dc.subjectRAR-ALPHAen
dc.subjectFENRETINIDEen
dc.subjectOncologyen
dc.titleRetinoid receptor alpha and beta expression in serous ovarian tumorsen
dc.typejournalArticleen


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