Angiopoietin-1 and angiopoietin-2 as serum biomarkers for ectopic pregnancy and missed abortion A case-control study
dc.creator | Daponte, A. | en |
dc.creator | Deligeoroglou, E. | en |
dc.creator | Pournaras, S. | en |
dc.creator | Tsezou, A. | en |
dc.creator | Garas, A. | en |
dc.creator | Anastasiadou, F. | en |
dc.creator | Hadjichristodoulou, C. | en |
dc.creator | Messinis, I. E. | en |
dc.date.accessioned | 2015-11-23T10:25:08Z | |
dc.date.available | 2015-11-23T10:25:08Z | |
dc.date.issued | 2013 | |
dc.identifier | 10.1016/j.cca.2012.10.031 | |
dc.identifier.issn | 0009-8981 | |
dc.identifier.uri | http://hdl.handle.net/11615/26892 | |
dc.description.abstract | Background: A case-control study to evaluate whether a single serum measurement of angiopoietin-1 (ANG-1) and angiopoietin-2 (ANG-2) at 6-8 weeks gestation can differentiate failed pregnancies, whether ectopic pregnancies (EP) or missed abortions (MA), from healthy intrauterine pregnancies (IUP). Intervention(s): Serum and tissue mRNA determination of ANG-1 and ANG-2 levels by ELISA and RTPCR, from 60 (30 EP and 30 MA) patients with failed early pregnancy and 33 IUPs. Results: ANG-1 and ANG-2 concentrations and their ratio are lower in EP (median, 689 and 302 pg/ml, respectively) and MA cases (median, 810 and 402 pg/ml, respectively) compared to IUP (median, 963 and 1477 pg/ml, respectively) (p<0.05, for all). Unlike ANG-2, serum ANG-1 discriminates an EP from a MA (p = 0.011). Trophoblastic ANG-1 mRNA expression levels are lower in EP compared to MA and IUP (p<0.05), while ANG-2 mRNA is higher in EP and MA than in IUP (p<0.05). Conclusions: A single measurement of serum ANG-1 and ANG-2 at 6-8 weeks of gestation designate the outcome of a pregnancy, as their levels are significantly decreased in failed than normal pregnancies. Serum ANG-1 showed potential to discriminate MA from EP. (c) 2012 Elsevier B.V. All rights reserved. | en |
dc.source.uri | <Go to ISI>://WOS:000314901900026 | |
dc.subject | Angiopoietin | en |
dc.subject | Abortion | en |
dc.subject | Ectopic pregnancy | en |
dc.subject | Biomarker | en |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | en |
dc.subject | HUMAN FETOPLACENTAL VASCULOGENESIS | en |
dc.subject | EARLY | en |
dc.subject | HUMAN PLACENTA | en |
dc.subject | TIE2 RECEPTOR | en |
dc.subject | 1ST TRIMESTER | en |
dc.subject | IN-VIVO | en |
dc.subject | ANGIOGENESIS | en |
dc.subject | EXPRESSION | en |
dc.subject | VEGF | en |
dc.subject | PREECLAMPSIA | en |
dc.subject | Medical Laboratory Technology | en |
dc.title | Angiopoietin-1 and angiopoietin-2 as serum biomarkers for ectopic pregnancy and missed abortion A case-control study | en |
dc.type | journalArticle | en |
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