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Interleukin-15 (IL-15) and Anti-C1q Antibodies as Serum Biomarkers for Ectopic Pregnancy and Missed Abortion
dc.creator | Daponte, A. | en |
dc.creator | Deligeoroglou, E. | en |
dc.creator | Pournaras, S. | en |
dc.creator | Hadjichristodoulou, C. | en |
dc.creator | Garas, A. | en |
dc.creator | Anastasiadou, F. | en |
dc.creator | Messinis, I. E. | en |
dc.date.accessioned | 2015-11-23T10:25:07Z | |
dc.date.available | 2015-11-23T10:25:07Z | |
dc.date.issued | 2013 | |
dc.identifier | 10.1155/2013/637513 | |
dc.identifier.issn | 1740-2522 | |
dc.identifier.uri | http://hdl.handle.net/11615/26891 | |
dc.description.abstract | Given the present lack of clinically useful tests for the accurate diagnosis of ectopic pregnancy (EP), there is a need to select out those immunological factors measured in the maternal serum, as potential biomarkers. Our assumption was that C1q/anti-C1q antibody complexes and serum levels of interleukin-15 (IL-15) may play a role in differentiating abortions (MAs) and EPs and normal pregnancies. We assessed whether their measurement could set the diagnosis in a case control study at 6-8 weeks consisting of 60 women with failed early pregnancy (30 EPs, 30 MAs) and 33 women with intrauterine pregnancies. Normal pregnancies contain anti-C1q antibodies more frequently compared to women with failed pregnancies, the lowest levels being found in EPs, but this lacked statistical significance and anti-C1q could not serve as a marker. However EP pregnancies had elevated IL-15 levels that could statistically significantly differentiate them from MAs and IUPs. Furthermore, when assessing IL-15 for the clinically important differentiation between IUP and EP, we found at a cut-off of 16 pg/mL a negative predictive value of 99 with a sensitivity for diagnosing an EP of 92%. According to these results, serum IL-15 is a promising marker differentiating an MA from an EP. | en |
dc.source | Clinical & Developmental Immunology | en |
dc.source.uri | <Go to ISI>://WOS:000314120800001 | |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | en |
dc.subject | PATHOGENIC ROLE | en |
dc.subject | AUTOANTIBODIES | en |
dc.subject | C1Q | en |
dc.subject | PROGESTERONE | en |
dc.subject | IMPLANTATION | en |
dc.subject | ENDOMETRIUM | en |
dc.subject | EXPRESSION | en |
dc.subject | MANAGEMENT | en |
dc.subject | CYTOKINES | en |
dc.subject | Immunology | en |
dc.title | Interleukin-15 (IL-15) and Anti-C1q Antibodies as Serum Biomarkers for Ectopic Pregnancy and Missed Abortion | en |
dc.type | journalArticle | en |
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