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The MoCA Well-suited screen for cognitive impairment in Parkinson disease
dc.creator | Dalrymple-Alford, J. C. | en |
dc.creator | MacAskill, M. R. | en |
dc.creator | Nakas, C. T. | en |
dc.creator | Livingston, L. | en |
dc.creator | Graham, C. | en |
dc.creator | Crucian, G. P. | en |
dc.creator | Melzer, T. R. | en |
dc.creator | Kirwan, J. | en |
dc.creator | Keenan, R. | en |
dc.creator | Wells, S. | en |
dc.creator | Porter, R. J. | en |
dc.creator | Watts, R. | en |
dc.creator | Anderson, T. J. | en |
dc.date.accessioned | 2015-11-23T10:25:05Z | |
dc.date.available | 2015-11-23T10:25:05Z | |
dc.date.issued | 2010 | |
dc.identifier | 10.1212/WNL.0b013e3181fc29c9 | |
dc.identifier.issn | 0028-3878 | |
dc.identifier.uri | http://hdl.handle.net/11615/26871 | |
dc.description.abstract | Objective: To establish the diagnostic accuracy of the Montreal Cognitive Assessment (MoCA) when screening externally validated cognition in Parkinson disease (PD), by comparison with a PD-focused test (Scales for Outcomes in Parkinson disease-Cognition [SCOPA-COG]) and the standardized Mini-Mental State Examination (S-MMSE) as benchmarks. Methods: A convenience sample of 114 patients with idiopathic PD and 47 healthy controls was examined in a movement disorders center. The 21 patients with dementia (PD-D) were diagnosed using Movement Disorders Society criteria, externally validated by detailed independent functional and neuropsychological tests. The 21 patients with mild cognitive impairment (PD-MCI) scored 1.5 SD or more below normative data in at least 2 measures in 1 of 4 cognitive domains. Other patients had normal cognition (PD-N). Results: Primary outcomes using receiver operating characteristic (ROC) curve analyses showed that all 3 mental status tests produced excellent discrimination of PD-D from patients without dementia (area under the curve [AUC], 87%-91%) and PD-MCI from PD-N patients (AUC, 78%-90%), but the MoCA was generally better suited across both assessments. The optimal MoCA screening cutoffs were <21/30 for PD-D (sensitivity 81%; specificity 95%; negative predictive value [NPV] 92%) and <26/30 for PD-MCI (sensitivity 90%; specificity 75%; NPV 95%). Further support that the MoCA is at least equivalent to the SCOPA-COG, and superior to the S-MMSE, came from the simultaneous classification of the 3 PD patient groups (volumes under a 3-dimensional ROC surface, chance = 17%: MoCA 79%, confidence interval [CI] 70%-89%; SCOPA-COG 74%, CI 62%-86%; MMSE-Sevens item 56%, CI 44%-68%; MMSE-World item 62%, CI 50%-73%). Conclusions: The MoCA is a suitably accurate, brief test when screening all levels of cognition in PD. Neurology(R) 2010;75:1717-1725 | en |
dc.source | Neurology | en |
dc.source.uri | <Go to ISI>://WOS:000284473000012 | |
dc.subject | NEUROPSYCHOLOGICAL CHARACTERISTICS | en |
dc.subject | RATING-SCALE | en |
dc.subject | DEMENTIA | en |
dc.subject | DISORDER | en |
dc.subject | INCIDENT | en |
dc.subject | DEFICITS | en |
dc.subject | MMSE | en |
dc.subject | TOOL | en |
dc.subject | Clinical Neurology | en |
dc.title | The MoCA Well-suited screen for cognitive impairment in Parkinson disease | en |
dc.type | journalArticle | en |
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