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Inhibin secretion in women with the polycystic ovary syndrome before and after treatment with progesterone
dc.creator | Dafopoulos, K. | en |
dc.creator | Venetis, C. | en |
dc.creator | Messini, C. I. | en |
dc.creator | Pournaras, S. | en |
dc.creator | Anifandis, G. | en |
dc.creator | Garas, A. | en |
dc.creator | Messinis, I. E. | en |
dc.date.accessioned | 2015-11-23T10:24:56Z | |
dc.date.available | 2015-11-23T10:24:56Z | |
dc.date.issued | 2011 | |
dc.identifier | 10.1186/1477-7827-9-59 | |
dc.identifier.issn | 1477-7827 | |
dc.identifier.uri | http://hdl.handle.net/11615/26797 | |
dc.description.abstract | Objectives: It has been suggested that inhibin secretion is altered in women with the polycystic ovary syndrome (PCOS). However, the contribution of a preceding luteal phase has not been taken into account. The aim of the present study was to investigate whether progesterone in the context of a simulated luteal phase affects basal and FSH-induced inhibin secretion in women with PCOS and elevated LH. Methods: Ten women with PCOS and 8 normally cycling women participated in an experimental procedure (Exp) involving the administration of a single injection of recombinant FSH (450 IU sc). In the women with PCOS, the procedure was performed before (Exp 1) and after a 20-day treatment with progesterone (Exp 2), while in the normal women on day 2 of the cycle (Exp 3). Inhibin A and B levels were measured in blood samples taken before and 24 hours after the FSH injection. Results: Basal LH levels were significantly higher and inhibin A levels were significantly lower in the PCOS group compared to the control group, while inhibin B levels were comparable in the two groups. In the PCOS group, after treatment with progesterone inhibin A and LH but not inhibin B levels decreased significantly (p < 0.05). After the FSH injection, inhibin A and B levels increased significantly in the women with PCOS (Exp 1 and Exp 2) but not in the control women (Exp 3). Conclusions: In women with PCOS, as compared to control women, the dissimilar pattern of inhibin A and inhibin B secretion in response to FSH appears to be independent of a preceding simulated luteal phase. It is possible that compared to normal ovaries, the PCOS ovaries are less sensitive to endogenous LH regarding inhibin A secretion and more sensitive to exogenous FSH stimulation in terms of inhibin A and inhibin B secretion. | en |
dc.source.uri | <Go to ISI>://WOS:000290728700001 | |
dc.subject | FOLLICLE-STIMULATING-HORMONE | en |
dc.subject | SURGE-ATTENUATING FACTOR | en |
dc.subject | LUTEINIZING-HORMONE | en |
dc.subject | SERUM INHIBIN | en |
dc.subject | DIFFERENTIAL REGULATION | en |
dc.subject | ESTRADIOL | en |
dc.subject | RESPONSES | en |
dc.subject | MENSTRUAL-CYCLE | en |
dc.subject | PHASE | en |
dc.subject | FSH | en |
dc.subject | INSULIN | en |
dc.subject | Endocrinology & Metabolism | en |
dc.subject | Reproductive Biology | en |
dc.title | Inhibin secretion in women with the polycystic ovary syndrome before and after treatment with progesterone | en |
dc.type | journalArticle | en |
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