Mostra i principali dati dell'item
The effect of estrogens on plasma ghrelin concentrations in women
dc.creator | Dafopoulos, K. | en |
dc.creator | Chalvatzas, N. | en |
dc.creator | Kosmas, G. | en |
dc.creator | Kallitsaris, A. | en |
dc.creator | Pournaras, S. | en |
dc.creator | Messinis, I. E. | en |
dc.date.accessioned | 2015-11-23T10:24:55Z | |
dc.date.available | 2015-11-23T10:24:55Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 0391-4097 | |
dc.identifier.uri | http://hdl.handle.net/11615/26786 | |
dc.description.abstract | Background: Data regarding the possible effects of estrogen on ghrelin secretion in humans are limited and contradictory. Aim: To investigate the effect of estradiol (E2) on ghrelin levels in normal pre- and post-menopausal women. Subjects and methods: A total of 21 women divided into 3 groups, i.e. 13 normally cycling women (no.=7, group 1 and no.=6, group 2) and 8 post-menopausal women (group 3). Women of group 1 received increasing doses of E2 through skin patches from cycle days 3 to 5. Women of group 2, underwent total abdominal hysterectomy plus bilateral salpingooophorectomy (TAH+BSO) on cycle day 3. Women of group 3 received po increasing doses of E2 valerate for 15 days. Acylated ghrelin and E2 were measured in all blood samples. Results: In group 1, plasma ghrelin levels did not show any significant changes for the week following cycle day 3. In group 2, ghrelin levels were similar before and after TAH+BSO and remained stable during the first 7 post-operative days. In group 3, no significant changes in plasma ghrelin levels were seen during the 15 days of E2 administration. Conclusions: The present study demonstrates for the first time that ghrelin values were not affected either by exogenous short-term estrogen administration to pre- and post-menopausal women or following ovariectomy in pre-menopausal women. It is suggested that ovarian hormones are not involved in the regulation of ghrelin secretion in women. (J. Endocrinol. Invest. 33: 109-112, 2010) (C) 2010, Editrice Kurtis | en |
dc.source.uri | <Go to ISI>://WOS:000277002300008 | |
dc.subject | Estrogens | en |
dc.subject | ghrelin | en |
dc.subject | women | en |
dc.subject | POSTMENOPAUSAL WOMEN | en |
dc.subject | CIRCULATING GHRELIN | en |
dc.subject | INSULIN-RESISTANCE | en |
dc.subject | METABOLIC | en |
dc.subject | SYNDROME | en |
dc.subject | RAT STOMACH | en |
dc.subject | LEPTIN | en |
dc.subject | THERAPY | en |
dc.subject | SECRETION | en |
dc.subject | PREGNANCY | en |
dc.subject | PEPTIDE | en |
dc.subject | Endocrinology & Metabolism | en |
dc.title | The effect of estrogens on plasma ghrelin concentrations in women | en |
dc.type | journalArticle | en |
Files in questo item
Files | Dimensione | Formato | Mostra |
---|---|---|---|
Nessun files in questo item. |