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Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients

dc.creatorClarimon, J.en
dc.creatorXiromerisiou, G.en
dc.creatorEerola, J.en
dc.creatorGourbali, V.en
dc.creatorHellstrom, O.en
dc.creatorDardiotis, E.en
dc.creatorPeuralinna, T.en
dc.creatorPapadimitriou, A.en
dc.creatorHadjigeorgiou, G. M.en
dc.creatorTienari, P. J.en
dc.creatorSingleton, A. B.en
dc.date.accessioned2015-11-23T10:24:48Z
dc.date.available2015-11-23T10:24:48Z
dc.date.issued2005
dc.identifier10.1186/1471-2377-5-11
dc.identifier.issn1471-2377
dc.identifier.urihttp://hdl.handle.net/11615/26729
dc.description.abstractBackground: Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations. Methods: Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland. Results: No association was found in any of the populations studied. Conclusion: Taken together, these findings suggest that common genetic variants in FGF20 are not a risk factor for PD in, at least, some European populations.en
dc.source.uri<Go to ISI>://WOS:000236187900001
dc.subjectFAMILIAL AGGREGATIONen
dc.subjectCLONINGen
dc.subjectClinical Neurologyen
dc.titleLack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patientsen
dc.typejournalArticleen


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