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Nocturnal hypertension is associated with an exacerbation of the endothelial damage in preeclampsia
dc.creator | Bouchlariotou, S. | en |
dc.creator | Liakopoulos, V. | en |
dc.creator | Dovas, S. | en |
dc.creator | Giannopoulou, M. | en |
dc.creator | Kiropoulos, T. | en |
dc.creator | Zarogiannis, S. | en |
dc.creator | Gatselos, G. | en |
dc.creator | Zachopoulos, T. | en |
dc.creator | Kyriakou, D. S. | en |
dc.creator | Kallitsaris, A. | en |
dc.creator | Messinis, I. | en |
dc.creator | Stefanidis, I. | en |
dc.date.accessioned | 2015-11-23T10:24:04Z | |
dc.date.available | 2015-11-23T10:24:04Z | |
dc.date.issued | 2008 | |
dc.identifier | 10.1159/000112807 | |
dc.identifier.issn | 0250-8095 | |
dc.identifier.uri | http://hdl.handle.net/11615/26389 | |
dc.description.abstract | Background: Non-dipping pattern of circadian blood pressure in preeclampsia is associated with an increased risk of cardiovascular disease. The pathogenetic mechanisms of this relationship are still unclear. We investigated whether non-dipping in preeclampsia could relate to endothelial activation or damage. Methods: Participants, 20 women with normal pregnancy (mean age 29.9 +/- 5.7 years) and 31 women with preeclampsia (mean age 29.1 +/- 5.1 years), underwent 24-hour ambulatory blood pressure monitoring. Plasma levels of von Willebrand factor (vWf), marker of endothelial damage and of soluble adhesion molecules (sVCAM-1, sICAM-1), and markers of endothelial activation were determined using commercially available enzyme-linked immunoassays. Results: Based on whether the nocturnal mean arterial pressure (MAP) relative to the daytime MAP declined by less than 10%, 21 women with preeclampsia were categorized as non-dippers. Compared to healthy pregnant women, patients with preeclampsia showed significantly enhanced levels of vWf (206.9 +/- 40.6 vs. 123 +/- 24 IU/dl; p < 0.01) and sVCAM-1 (2,269 +/- 426 vs. 1,159.+/- 8 340 ng/ml; p < 0.01). In addition, significantly higher levels of vWf (224.5 +/- 34.9 vs. 170 +/- 23 IU/dl; p < 0.01) and sVCAM-1 (2,405 +/- 421.4 vs. 1,983 +/- 276.7 ng/ml; p = 0.007) were determined, when women with preeclampsia and nocturnal hypertension (non-dippers) were compared to dippers. The results were similar even after adjustment for severity of preeclampsia. In contrast, neither preeclampsia nor dipping status had an effect on sICAM-1 levels. Conclusion: Nocturnal hypertension in preeclampsia is associated with elevated levels of molecules related to endothelial damage. Endothelial damage is a recognized pathogenetic factor for atherosclerosis and history of preeclampsia is a risk factor for cardiovascular disease. In this context, possible clinical implications of our findings deserve further investigation. Copyright (C) 2007 S. Karger AG, Basel. | en |
dc.source | American Journal of Nephrology | en |
dc.source.uri | <Go to ISI>://WOS:000253777700009 | |
dc.subject | blood pressure | en |
dc.subject | circadian rhythm | en |
dc.subject | endothelial damage | en |
dc.subject | preeclampsia | en |
dc.subject | VON-WILLEBRAND-FACTOR | en |
dc.subject | BLOOD-PRESSURE VARIABILITY | en |
dc.subject | ADHESION MOLECULE | en |
dc.subject | DISEASE | en |
dc.subject | PREGNANCY | en |
dc.subject | RISK | en |
dc.subject | CELLS | en |
dc.subject | VCAM-1 | en |
dc.subject | Urology & Nephrology | en |
dc.title | Nocturnal hypertension is associated with an exacerbation of the endothelial damage in preeclampsia | en |
dc.type | journalArticle | en |
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