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Can statin therapy reduce the risk of melanoma? A meta-analysis of randomized controlled trials
dc.creator | Bonovas, S. | en |
dc.creator | Nikolopoulos, G. | en |
dc.creator | Filioussi, K. | en |
dc.creator | Peponi, E. | en |
dc.creator | Bagos, P. | en |
dc.creator | Sitaras, N. M. | en |
dc.date.accessioned | 2015-11-23T10:24:00Z | |
dc.date.available | 2015-11-23T10:24:00Z | |
dc.date.issued | 2010 | |
dc.identifier | 10.1007/s10654-009-9396-x | |
dc.identifier.issn | 0393-2990 | |
dc.identifier.uri | http://hdl.handle.net/11615/26356 | |
dc.description.abstract | A growing body of literature suggests that statins may have a chemopreventive potential against melanoma through pleiotropic anti-inflammatory, immunomodulatory, and antiangiogenesis mechanisms. Our aim was to examine this association through a detailed meta-analysis of randomized controlled trials (RCTs). A comprehensive search for trials published up to June 2009 was performed, reviews of each study were conducted and data were abstracted. Prior to meta-analysis, the studies were evaluated for publication bias and heterogeneity. Pooled relative risk estimates (RR) and 95% confidence intervals (CIs) were calculated using the fixed- and the random-effects models. Subgroup and sensitivity analyses were also conducted. Sixteen RCTs of statins for cardiovascular outcomes, involving 62,568 individuals with a mean age of 60 years and an average follow-up of nearly 4.7 years, contributed to the analysis. We found no evidence of publication bias (P = 0.47) or heterogeneity among the studies (P = 0.25). Statin use did not significantly affect the risk of developing melanoma assuming either a fixed- (RR = 0.92, 95% CI: 0.67-1.26), or a random-effects model (RR = 0.92, 95% CI: 0.62-1.36). This neutral effect was further supported by the results of subgroup and sensitivity analyses. Our findings do not support a protective effect of statins against melanoma. | en |
dc.source | European Journal of Epidemiology | en |
dc.source.uri | <Go to ISI>://WOS:000273745500005 | |
dc.subject | Chemoprevention | en |
dc.subject | 3-Hydroxy-3-methylglutaryl-coenzyme A reductase | en |
dc.subject | inhibitors | en |
dc.subject | Melanoma | en |
dc.subject | Statins | en |
dc.subject | AVERAGE CHOLESTEROL LEVELS | en |
dc.subject | CORONARY-HEART-DISEASE | en |
dc.subject | CLINICAL-TRIALS | en |
dc.subject | CANCER-RISK | en |
dc.subject | PREVENTION | en |
dc.subject | CELLS | en |
dc.subject | SIMVASTATIN | en |
dc.subject | PRAVASTATIN | en |
dc.subject | LOVASTATIN | en |
dc.subject | QUALITY | en |
dc.subject | Public, Environmental & Occupational Health | en |
dc.title | Can statin therapy reduce the risk of melanoma? A meta-analysis of randomized controlled trials | en |
dc.type | journalArticle | en |
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