dc.creator | Bath, P. M. W. | en |
dc.creator | Adami, A. | en |
dc.creator | Bereczki, D. | en |
dc.creator | Berge, E. | en |
dc.creator | Beridze, M. | en |
dc.creator | Cala, L. | en |
dc.creator | Casado, A. | en |
dc.creator | Caso, V. | en |
dc.creator | Chang, H. M. | en |
dc.creator | Christensen, H. | en |
dc.creator | Collins, R. | en |
dc.creator | Czlonkowska, A. | en |
dc.creator | Dineen, R. A. | en |
dc.creator | El Etribi, A. | en |
dc.creator | Ghani, A. R. | en |
dc.creator | Gommans, J. | en |
dc.creator | Koumellis, P. | en |
dc.creator | Laska, A. C. | en |
dc.creator | Lees, K. R. | en |
dc.creator | Navarro, J. | en |
dc.creator | Ntaios, G. | en |
dc.creator | Ozturk, S. | en |
dc.creator | Phillips, S. | en |
dc.creator | Pocock, S. | en |
dc.creator | Prasad, K. | en |
dc.creator | Scutt, P. | en |
dc.creator | de Silva, H. A. | en |
dc.creator | Szatmari, S. | en |
dc.creator | Diez-Tejedor, E. | en |
dc.creator | Utton, S. | en |
dc.creator | Wang, Y. J. | en |
dc.creator | Wardlaw, J. M. | en |
dc.creator | Whynes, D. | en |
dc.creator | Wong, L. | en |
dc.creator | Woodhouse, L. | en |
dc.creator | Sprigg, N. | en |
dc.creator | Investigators, Enos | en |
dc.date.accessioned | 2015-11-23T10:23:39Z | |
dc.date.available | 2015-11-23T10:23:39Z | |
dc.date.issued | 2014 | |
dc.identifier | 10.1111/ijs.12308 | |
dc.identifier.issn | 1747-4930 | |
dc.identifier.uri | http://hdl.handle.net/11615/26195 | |
dc.description.abstract | Background High blood pressure is common in acute stroke and associated with a worse functional outcome. Many patients who present with acute stroke are taking prescribed antihypertensive therapy before their stroke. Aims ENOS tested whether lowering blood pressure and continuing pre-stroke antihypertensive therapy are each safe and effective. Methods This study is an international multi-centre prospective randomized single-blind blinded-endpoint parallel-group partial-factorial controlled trial of transdermal glyceryl trinitrate (a nitric oxide donor, given for seven-days) vs. no glyceryl trinitrate, and of continuing vs. stopping (temporarily for seven-days) pre-stroke antihypertensive drugs if relevant, in patients with acute ischaemic stroke or intracerebral haemorrhage and high systolic blood pressure (140-220 mmHg). Results Recruitment ran from July 2001 to October 2013. Four thousand eleven patients [2097 (52.3%) in the continue/stop arm] were recruited from 173 sites across 23 countries in 5 continents (Asia 14%, Continental Europe 16%, UK 64%). Baseline characteristics include: mean age 70 (standard deviation 12) years; male 57%; mean time from stroke to recruitment 26 (13) h; mean severity (Scandinavian Stroke Scale) 34 (13) of 58; mean blood pressure 167 (19)/90 (13) mmHg; ischaemic stroke 83%; and intracerebral haemorrhage 16%. The main trial results will be presented in May 2014. The results will also be presented in updated Cochrane systematic reviews and included in individual patient data meta-analyses of all relevant randomized controlled trials. Conclusion ENOS is a large completed international trial of blood pressure management in acute stroke and includes patients representative of many stroke services worldwide. | en |
dc.source | International Journal of Stroke | en |
dc.source.uri | <Go to ISI>://WOS:000339477400012 | |
dc.subject | acute stroke | en |
dc.subject | antihypertensive drugs | en |
dc.subject | blood pressure | en |
dc.subject | glyceryl | en |
dc.subject | trinitrate | en |
dc.subject | nitric oxide | en |
dc.subject | randomized controlled trial | en |
dc.subject | ACUTE ISCHEMIC-STROKE | en |
dc.subject | TRANSDERMAL GLYCERYL TRINITRATE | en |
dc.subject | BLOOD-PRESSURE | en |
dc.subject | STATISTICAL-ANALYSIS | en |
dc.subject | CLINICAL-TRIAL | en |
dc.subject | RATIONALE | en |
dc.subject | OUTCOMES | en |
dc.subject | DESIGN | en |
dc.subject | SCALE | en |
dc.subject | Peripheral Vascular Disease | en |
dc.title | Baseline characteristics of the 4011 patients recruited into the 'Efficacy of Nitric Oxide in Stroke' (ENOS) trial | en |
dc.type | journalArticle | en |