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Methylation status of RASSF1A in patients with chronic myeloid leukemia

dc.creatorAvramouli, A.en
dc.creatorTsochas, S.en
dc.creatorMandala, E.en
dc.creatorKatodritou, E.en
dc.creatorIoannou, M.en
dc.creatorRitis, K.en
dc.creatorSpeletas, M.en
dc.date.accessioned2015-11-23T10:23:22Z
dc.date.available2015-11-23T10:23:22Z
dc.date.issued2009
dc.identifier10.1016/j.leukres.2009.01.003
dc.identifier.issn0145-2126
dc.identifier.urihttp://hdl.handle.net/11615/26064
dc.description.abstractRASSF1A, a key cell cycle related gene, is expressed in all hematopoietic cells, it is implicated in ras signaling pathway and its promoter hypermethylation is observed in a wide variety of solid tumors. Till now, RASSF1A methylation status has not been investigated in patients with chronic myeloid leukemia (CML). In this study, we analyzed 41 patients carrying the BCR-ABL rearrangement, in different stages of the disease. No patient displayed RASSF1A promoter methylation, although the K562 erythroleukemia cell line, bearing the BCR-ABL rearrangement, was found methylated. Thus, our findings indicate that RASSF1A methylation does not appear to represent a critical step in the pathogenesis and/or the progression of CML. (C) 2009 Elsevier Ltd. All rights reserved.en
dc.sourceLeukemia Researchen
dc.source.uri<Go to ISI>://WOS:000266759000024
dc.subjectChronic myeloid leukemiaen
dc.subjectRASSF1Aen
dc.subjectMethylationen
dc.subjectHEMATOLOGIC MALIGNANCIESen
dc.subjectGENEen
dc.subjectOncologyen
dc.subjectHematologyen
dc.titleMethylation status of RASSF1A in patients with chronic myeloid leukemiaen
dc.typejournalArticleen


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