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Nasal corticosteroids for children with snoring
dc.creator | Alexopoulos, E. I. | en |
dc.creator | Kaditis, A. G. | en |
dc.creator | Kalampouka, E. | en |
dc.creator | Kostadima, E. | en |
dc.creator | Angelopoulos, N. V. | en |
dc.creator | Mikraki, V. | en |
dc.creator | Skenteris, N. | en |
dc.creator | Gourgoulianis, K. | en |
dc.date.accessioned | 2015-11-23T10:22:00Z | |
dc.date.available | 2015-11-23T10:22:00Z | |
dc.date.issued | 2004 | |
dc.identifier | 10.1002/ppul.20079 | |
dc.identifier.issn | 8755-6863 | |
dc.identifier.uri | http://hdl.handle.net/11615/25464 | |
dc.description.abstract | Nasal corticosteroids improve polysomnography indices but not symptoms in children with mild to moderate sleep-disordered breathing. We hypothesized that administration of nasal corticosteroids for 4 weeks to snoring children with only mild elevation in their apnea-hypopnea index would improve both polysomnography findings and symptoms of sleep-disordered breathing. Budesonide 50 mcg per nostril twice daily was administered for 4 weeks to children (2-14 years old) with habitual snoring and an apnea-hypopnea index of 1-10 episodes/hr. Subjects were evaluated before treatment and at 2 weeks and 9 months after its completion. Primary outcome variables were changes in apnea-hypopnea index and symptom score. Twenty-seven children were studied. At 2 weeks, the mean apnea-hypopnea index decreased from 5.2 (+/-2.2) episodes/hr to 3.2 (+/-1.5) episodes/hr, and median oxygen desaturation of hemoglobin index fell from 3.1 (0.4-8.2) to 1.9 (0.2-5.4) (P < 0.0001). Mean symptom score was 1.33 (+/-2.11) at baseline, and decreased to -0.008 (+/-2.24) at 2 weeks after treatment and to -1.08 (+/-1.75) at 9 months after treatment (P < 0.05). Four weeks of nasal budesonide improved both polysomnography findings and symptoms in children with mild sleep-disordered breathing. The clinical effect is maintained for several months after treatment. (C) 2004 Wiley-Liss, Inc. | en |
dc.source | Pediatric Pulmonology | en |
dc.source.uri | <Go to ISI>://WOS:000222857500011 | |
dc.subject | adenoidectomy | en |
dc.subject | obstructive sleep apnea | en |
dc.subject | snoring | en |
dc.subject | tonsillectomy | en |
dc.subject | OBSTRUCTIVE SLEEP-APNEA | en |
dc.subject | UPPER AIRWAY | en |
dc.subject | SPRAY | en |
dc.subject | COLLAPSIBILITY | en |
dc.subject | BECLOMETHASONE | en |
dc.subject | HYPERTROPHY | en |
dc.subject | ADENOIDS | en |
dc.subject | STEROIDS | en |
dc.subject | TONSILS | en |
dc.subject | Pediatrics | en |
dc.subject | Respiratory System | en |
dc.title | Nasal corticosteroids for children with snoring | en |
dc.type | journalArticle | en |
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