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Effects of obstructive sleep apnea severity on serum lipid levels in Greek children with snoring

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Author
Alexopoulos, E. I.; Gletsou, E.; Kostadima, E.; Kaditis, D.; Zakynthinos, E.; Gourgoulianis, K.; Kaditis, A.
Date
2011
DOI
10.1007/s11325-010-0410-z
Keyword
Atherosclerosis
Obstructive sleep apnea
Serum Lipids
Snoring
NUTRITION EXAMINATION SURVEY
CARDIOVASCULAR RISK-FACTORS
3RD
NATIONAL-HEALTH
INTERMITTENT HYPOXIA
METABOLIC SYNDROME
INSULIN-RESISTANCE
NONOBESE CHILDREN
HEART HEALTH
LEAN MICE
ADOLESCENTS
Clinical Neurology
Respiratory System
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Abstract
Although obstructive sleep apnea (OSA) is related to dyslipidemia in adults, limited data are available regarding its effects on serum lipids during childhood. Aim of this study was to assess the potential relationships between severity of OSA and cholesterol or triglyceride levels in a cohort of Greek children. Data from children with snoring who underwent polysomnography and complete serum lipids measurements during a specified study period were analyzed retrospectively. Overall, obese children (n = 261) had lower HDL cholesterol levels than non-obese subjects (n = 113) (49.6 +/- 10.5 vs. 53.9 +/- 11.4 mg/dL; p = 0.001) and higher triglyceride concentrations (69.8 +/- 32.2 vs. 63.2 +/- 27 mg/dL; p = 0.041). Non-obese subjects with moderate-to-severe OSA did not differ in triglycerides, total, and LDL cholesterol concentrations but had lower HDL cholesterol, when compared to non-obese children with primary snoring/mild OSA (50.4 +/- 13.1 vs. 54.9 +/- 10.7 mg/dL; p = 0.008). The risk for having low HDL cholesterol (a parts per thousand currency sign40 mg/dL) was threefold higher in non-obese subjects with moderate-to-severe OSA than in those with primary snoring/mild OSA, even after adjustment for age and gender [OR = 3.44 (95% CI 1.44 to 8.24; p = 0.006)]. Concentrations of serum lipids in obese children were not associated with severity of OSA. HDL cholesterol was 48.5 +/- 8.7 mg/dL in subjects with moderate-to-severe OSA and 50.0 +/- 11.1 mg/dL in children with primary snoring/mild OSA (p = 0.519). HDL cholesterol levels are inversely related to severity of OSA in non-obese children with snoring.
URI
http://hdl.handle.net/11615/25463
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  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [9728]
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