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Modulation of Poly(A)-specific Ribonuclease (PARN): Current Knowledge and Perspectives
(2012)
Deadenylation is the exoribonucleolytic shortening of eukaryotic poly(A) tails. It is often the first and rate-limiting step for mRNA decay and translational silencing. The process is catalysed by a diversity of deadenylases, ...
Glycosaminoglycans as Key Molecules in Atherosclerosis: The Role of Versican and Hyaluronan
(2010)
Cardiovascular disease is the largest cause of death in Western societies and it primarily results from atherosclerosis of large and medium-sized vessels. Atherosclerosis leads to myocardial infarction, when it occurs in ...
Enzymes as Target Antigens of Liver-Specific Autoimmunity: The Case of Cytochromes P450s
(2008)
Characterization of liver-specific autoantigens has given a fresh impetus to research in the pathogenesis of autoimmune liver diseases, viral-triggered and drug-induced autoimmunity affecting the liver. Intriguing is the ...
Biomarkers Obtained by Non-Invasive Methods in Patients with COPD: Where do we Stand, what do we Expect?
(2009)
Recently, there has been widespread interest in the use of non-invasive methods for the assessment of airway inflammation in a variety of lung diseases including chronic obstructive pulmonary disease ( COPD). Sputum induction ...
Epigenetic Mechanisms and Kidney Diseases
(2011)
In recent years, molecular research has brought to light a series of mechanisms involved in the regulation of gene function without altering the DNA sequence. These mechanisms are described with the term "epigenetics" and ...
Exhaled Nitric Oxide in Asthma in Adults: The End is the Beginning?
(2011)
Approximately 20 years after the initial report of the measurement of exhaled nitric oxide (NO) in the exhaled air of humans, numerous publications have evaluated the possible applications of the fraction of exhaled NO ...
Matrix Metalloproteinases in Respiratory Diseases: From Pathogenesis to Potential Clinical Implications
(2009)
Matrix metalloproteinases (MMPs) are zinc-endopeptidases responsible for degradation of the extracellular matrix (ECM) components including basement membrane collagen, interstitial collagen, fibronectin, and various ...