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Low-Density Lipoprotein Receptor-Related Protein 5 (LRP5) Expression in Human Osteoarthritic Chondrocytes
(2010)
The aim of this study was to investigate the activation of the Wnt/beta-catenin pathway in osteoarthritis and the role of low-density lipoprotein receptor-related protein 5 (LRP5) in human osteoarthritic chondrocytes. The ...
Asporin and knee osteoarthritis in patients of Greek origin
(2006)
Ostearthritis (OA) is characterized by focal areas of loss of the articular cartilage in synovial joints, associated with varying degrees of osteophyte formation, subchondral bone change and synovitis. The Asporin (ASPN) ...
Protective Effect of Atorvastatin in Cultured Osteoarthritic Chondrocytes
(2010)
The aim of our study was to evaluate the in vitro effect of an HMG-CoA reductase inhibitor, atorvastatin, on the expression of significant anabolic and catabolic genes in human osteoarthritic chondrocytes and to explore ...
Impaired Expression of Genes Regulating Cholesterol Efflux in Human Osteoarthritic Chondrocytes
(2010)
Altered lipid metabolism has been implicated as a critical player in osteoarthritis (OA). Our study aimed to investigate the expression of genes regulating cholesterol efflux in human chondrocytes and to study the effect ...
A large-scale replication study for the association of rs17039192 in HIF-2 alpha with knee osteoarthritis
(2012)
Osteoarthritis (OA) is a common disease with a genetic component for its etiology. Recently, a genetic association of a single nucleotide polymorphism (SNP), rs17039192 in HIF-2a with knee OA has been reported in a Japanese ...