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Studies on the Essential Intramolecular Interaction Between the A1 and A2 Domains of von Willebrand Factor
(2013)
Haemostasis depends on the balanced participation of von Willebrand factor (vWF), a large multimeric and multidomain glycoprotein with essential role during the initial steps of blood clotting. Mature vWF circulates in ...
The contribution of the zinc-finger motif to the function of Thermus thermophilus ribosomal protein S14
(2007)
In the crystal structure of the 30S ribosomal subunit from Thermus thermophilus, cysteine 24 of ribosomal protein S14 (TthS14) occupies the first position in a CXXC-X12-CXXC motif that coordinates a zinc ion. The structural ...
Critical role of residues defining the ligand binding pocket in hepatocyte nuclear factor-4 alpha
(2004)
Hepatocyte nuclear factor-4alpha (HNF-4alpha), a member of the nuclear receptor superfamily, is a crucial regulator of a large number of genes involved in glucose, cholesterol, and fatty acid metabolism. Unlike other members ...