OBJECTIVE Pituitary responsiveness to GnRH varies throughout the normal menstrual cycle, We have investigated whether there are differences in the ovarian mechanisms which regulate gonadotrophin secretion between the ...

The recent discovery of the obese (ob) gene has provided new insight into the mechanism which controls body fat mass. Leptin, a product of the ob gene, serves as the link between fat and the brain. This protein, by acting ...

It has been reported that oestradiol may play a role in the production of leptin from adipocytes, To investigate this relationship further, nine normally ovulating women were studied during two menstrual cycles, i.e. an ...

To study the relationships between gonadal steroids and leptin, 20 women with normal cycles were investigated during the postoperative period following a laparotomy. Fourteen women underwent bilateral ovariectomy plus total ...

Great progress has been achieved during the last 20 years in the field of ovulation induction in patients with polycystic ovary syndrome (PCOS). Clomiphene citrate remains the first line of treatment for all anovulatory ...

Objective: To study the mechanism through which mifepristone interrupts folliculogenesis. Design: Normally ovulating women undergoing donor intrauterine insemination (IUI) treatment were investigated during two menstrual ...

Oestradiol enhances pituitary sensitivity to gonadotrophin-releasing hormone (GnRH) in normal women, while in women undergoing ovulation induction the putative factor gonadotrophin surge attenuating factor (GnSAF) attenuates ...

Superovulation induction in women attenuates the pituitary response to gonadotropin-releasing hormone (GnRH). The aim of this study was to assess the duration of the suppressing activity of the ovaries on the pituitary. ...