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Involvement of SOX-9 and FGF-23 in RUNX-2 regulation in osteoarthritic chondrocytes

Orfanidou, T.; Iliopoulos, D.; Malizos, K. N.; Tsezou, A. (2009)

Chondrocytes' hypertrophy includes metabolic changes, matrix remodelling, proliferation and apoptosis, characteristics associated with the progression of osteoarthritis. We investigated a possible association among ...

Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism

Simopoulou, T.; Malizos, K. N.; Iliopoulos, D.; Stefanou, N.; Papatheodorou, L.; Ioannou, M.; Tsezou, A. (2007)

Objective: To investigate leptin's effect on cartilage metabolism and the pathophysiology of osteoarthritis (OA). Methods: Messenger RNA (mRNA) expression and protein levels of leptin and leptin's receptor isoforms were ...

Impaired Expression of Genes Regulating Cholesterol Efflux in Human Osteoarthritic Chondrocytes

Tsezou, A.; Iliopoulos, D.; Malizos, K. N.; Simopoulou, T. (2010)

Altered lipid metabolism has been implicated as a critical player in osteoarthritis (OA). Our study aimed to investigate the expression of genes regulating cholesterol efflux in human chondrocytes and to study the effect ...

Central Role of SREBP-2 in the Pathogenesis of Osteoarthritis

Kostopoulou, F.; Gkretsi, V.; Malizos, K. N.; Iliopoulos, D.; Oikonomou, P.; Poultsides, L.; Tsezou, A. (2012)

Background: Recent studies have implied that osteoarthritis (OA) is a metabolic disease linked to deregulation of genes involved in lipid metabolism and cholesterol efflux. Sterol Regulatory Element Binding Proteins (SREBPs) ...

Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention

Iliopoulos, D.; Malizos, K. N.; Tsezou, A. (2007)

Objective: To investigate whether epigenetic mechanisms can regulate leptin's expression and affect its downstream targets as metalloproteinases 3,9,13 in osteoarthritic chondrocytes. Methods: DNA methylation in leptin ...

Integrative MicroRNA and Proteomic Approaches Identify Novel Osteoarthritis Genes and Their Collaborative Metabolic and Inflammatory Networks

Iliopoulos, D.; Malizos, K. N.; Oikonomou, P.; Tsezou, A. (2008)

Background: Osteoarthritis is a multifactorial disease characterized by destruction of the articular cartilage due to genetic, mechanical and environmental components affecting more than 100 million individuals all over ...