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Long-term exposure to muscarinic agonists decreases expression of contractile proteins and responsiveness of rabbit tracheal smooth muscle cells
(2014)
Background: Chronic airway diseases, like asthma or COPD, are characterized by excessive acetylcholine release and airway remodeling. The aim of this study was to investigate the long-term effect of muscarinic agonists on ...
Comparison of the electrophysiological properties of the sheep isolated costal and diaphragmatic parietal pleura
(2007)
1. Pleural permeability may contribute to pleural fluid turnover. The transmesothelial resistance (R-TM), is an established surrogate of mesothelial permeability. The aim of the present study was to compare the ...
Insulin causes a transient induction of proliferation via activation of the PI3-kinase pathway in airway smooth muscle cells
(2007)
Insulin regulates glucose metabolism and activates cell growth. As the respiratory system is an alternative route for insulin administration in patients with diabetes mellitus, we studied the effect of insulin on rabbit ...
Matrix metalloproteinases 2 and 9 increase permeability of sheep pleura in vitro
(2012)
Background: Matrix metalloproteinases (MMPs) 2 and 9 are two gelatinase members which have been found elevated in exudative pleural effusions. In endothelial cells these MMPs increase paracellular permeability via the ...
Non-genomic effect of testosterone on airway smooth muscle
(2006)
Background and purpose: Recent studies on blood vessels have provided evidence that testosterone may exert direct effects on smooth muscle. However, an acute effect on airway reactivity has not been shown yet. The aim of ...