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Antimitochondrial antibodies of immunoglobulin G3 subclass are associated with a more severe disease course in primary biliary cirrhosis
(2007)
Background/Aims: Primary biliary cirrhosis (PBC) is characterised by the presence of immunoglobulin (Ig) G antimitochondrial antibodies (AMA), which are routinely detected by indirect immunofluorescence (IFL) using composite ...
An immunocompetent patient presenting with severe septic arthritis due to Ralstonia pickettii identified by molecular-based assays: A case report
(2009)
Introduction: Ralstonia pickettii is an infrequent pathogen of invasive infections in healthy individuals. The microorganism is supposed to be of relatively low virulence, but can cause infections, mainly of the respiratory ...
Cytochrome P450 2A6: a new hepatic autoantigen in patients with chronic hepatitis C virus infection
(2003)
Background/Aims: Cytochromes P4502A6 (CYP2A6) and P4501A2 (CYP1A2) were described as hepatic autoantigens in the autoimmune polyglandular syndrome type-1 (APS-1). We evaluated the significance of anti-CYP2A6 and anti-CYP1A2 ...
Bone marrow findings in patients with autoimmune liver diseases
(2008)
Background and Aims: We have recently reported quantitative and qualitative differences of the bone marrow (BM) hematopoietic progenitor cells in autoimmune hepatitis type-1 (AIH-1) and primary biliary cirrhosis (PBC). In ...
Anti-alpha-actinin antibodies cross-react with Anti-ssDNA antibodies in active autoimmune hepatitis
(2008)
Recently, we have observed that the association of anti-F-actin autoantibodies (Abs) with anti-alpha-actinin Abs (double reactivity) was correlated with liver disease activity in autoimmune hepatitis type 1 (AIH-1; Gueguen ...
Autoimmune hepatitis type 1 and primary biliary cirrhosis have distinct bone marrow cytokine production
(2005)
We have recently reported differences in the hematopoiesis between autoimmune hepatitis type I (AIH-1) and primary biliary cirrhosis (PBC). In view of the notion that cytokines are regulators of hematopoiesis, we investigated ...
A case of membranous nephropathy associated with Sjogren syndrome, polymyositis and autoimmune hepatitis
(2008)
Sjogren syndrome (SS) is a chronic systemic autoimmune disease characterized by lymphocylic infiltration of exocrine glands, especially lacrimal and salivary. The immunologic process which occurs in this syndrome is B cell ...
Enzymes as Target Antigens of Liver-Specific Autoimmunity: The Case of Cytochromes P450s
(2008)
Characterization of liver-specific autoantigens has given a fresh impetus to research in the pathogenesis of autoimmune liver diseases, viral-triggered and drug-induced autoimmunity affecting the liver. Intriguing is the ...