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Dichloroacetate at therapeutic concentration alters glucose metabolism and induces regulatory t-cell differentiation in alloreactive human lymphocytes
(2013)
Background: Most cancer cells rely on aerobic glycolysis. Dichloroacetate (DCA) inhibits aerobic glycolysis and is a promising relatively nontoxic anticancer compound. However, rapidly proliferating effector T-cells also ...
A single-blind randomized controlled trial to evaluate the effect of 6 months of progressive aerobic exercise training in patients with uraemic restless legs syndrome
(2013)
Background. Uraemic restless legs syndrome (RLS) affects a significant proportion of patients receiving haemodialysis (HD) therapy. Exercise training has been shown to improve RLS symptoms in uraemic RLS patients; however, ...
Endothelin-1 Acutely Reduces the Permeability of Visceral Sheep Peritoneum In Vitro Through Both Endothelin-A and Endothelin-B Receptors
(2013)
Mesothelium is an important part of the peritoneal barrier for water and ion transport, essential for effective peritoneal dialysis (PD). Peritoneal fibrosis has been associated with PD treatment failure. Endothelin-1 ...
Telomere Length in Peripheral Blood Mononuclear Cells of Patients on Chronic Hemodialysis Is Related With Telomerase Activity and Treatment Duration
(2015)
Telomere shortening to a critical limit is associated with replicative senescence. This process is prevented by the enzyme telomerase. Oxidative stress and chronic inflammation are factors accelerating telomere loss. Chronic ...
Uremic Versus Idiopathic Restless Legs Syndrome: Impact on Aspects Related to Quality of Life
(2012)
Restless legs syndrome (RLS) affects both the general population and patients with chronic renal failure. Even though it has been suggested that all forms of RLS share a common pathophysi-ology, not much evidence exists ...
Non-Pharmacological Management of Periodic Limb Movements During Hemodialysis Session in Patients With Uremic Restless Legs Syndrome
(2010)
Restless legs syndrome (RLS) is very common in hemodialysis patients. RLS induces motor excitability and discomfort during rest periods, and those symptoms have also been observed during hemodialysis sessions. The aim of ...
The Effect of Prolonged Intradialytic Exercise in Hemodialysis Efficiency Indices
(2011)
Optimal hemodialysis (HD) dose is very important to patients' health and survival, and various indices of adequacy have been incorporated into the current clinical practice to monitor HD efficiency. Exercise during HD could ...