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Inhibition of calcitriol inactivating enzyme CYP24A1 gene expression by flavonoids in hepatocellular carcinoma cells under normoxia and hypoxia
(2021)
A vast number of epidemiological, preclinical and in vitro experimental data strongly indicate the anticancer potential of calcitriol, the biologically active form of vitamin D. However, for the implementation of a vitamin ...
Parkinson's disease and pesticides: Are microRNAs the missing link?
(2020)
Parkinson's disease (PD) is a common neurodegenerative disorder that leads to significant morbidity and decline in the quality of life. It develops due to loss of dopaminergic neurons in the substantia nigra pars compacta, ...
Cardiopulmonary exercise testing in patients with asthma: What is its clinical value?
(2020)
Asthma is one of the most common respiratory disorders, characterized by fully or largely reversible airflow limitation. Asthma symptoms can be triggered or magnified during exertion, while physical activity limitation is ...
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture
(2021)
The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this ...
Immune checkpoint inhibitor-induced musculoskeletal manifestations
(2021)
Immune checkpoint inhibitors (ICI) associate with a wide range of immune-related adverse events (Ir-AE), including musculoskeletal manifestations. We aimed at identifying all studies reporting musculoskeletal Ir-AE. An ...
Rectifying the misconceptions about current best management of asymptomatic carotid stenosis is not about revising history
(2020)
[No abstract available]
Potential role of immunotherapy for advanced breast cancer
(2021)
[No abstract available]
Focus on the use of resveratrol as an adjuvant in glioblastoma therapy
(2020)
Glioblastoma (GB) represents the most common and malignant form of glioma cancer. The Gold Standard in Glioblastoma is neurosurgical tumor removal and radiotherapy treatment in concomitant with temo-zolomide (TMZ). ...
Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium
(2020)
Aims: Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for ...
Quantitative proteomics of cerebrospinal fluid using tandem mass tags in dogs with recurrent epileptic seizures
(2021)
This prospective study included four dog groups (group A: healthy dogs, groups B: dogs with idiopathic epilepsy under antiepileptic medication (AEM), C: idiopathic epilepsy dogs without AEM administration, D: dogs with ...