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Clinical, functional and biochemical changes during recovery from COPD exacerbations
(2009)
The pathways underlying chronic obstructive pulmonary disease exacerbations (ECOPD) remain unclear. This study describes the clinical., functional and biochemical changes during recovery from ECOPD. Thirty hospitalized ...
Global assessment of the COPD patient: Time to look beyond FEV1?
(2009)
COPD is a diverse disease entity with multiple dimensions that uniquely define the patient's performance, morbidity and mortality. FEV1 is both the traditional metric used to define the progression of COPD as well as the ...
One-year non-invasive ventilation in chronic hypercapnic COPD: Effect on quality of life
(2008)
The data on long-term application of non-invasive ventilation (NIV) in patients with chronic respiratory failure due to COPD are contradictory. We evaluated the effect of the addition of NIV to optimal treatment for 1 year ...
Comparison of a network of primary care physicians and an open spirometry programme for COPD diagnosis
(2011)
Background: Early diagnosis of Chronic Obstructive Pulmonary Disease (COPD) remains the cornerstone for effective management. In this study we compared an open spirometry programme and a case-finding programme providing ...
Adrenomedullin optimises mortality prediction in COPD patients
(2015)
Background: Current multicomponent scores that predict mortality in COPD patients might underestimate the systemic component of COPD. Therefore, we evaluated the accuracy of circulating levels of proadrenomedullin (MR-proADM) ...
Secondhand smoke exposure induces acutely airway acidification and oxidative stress
(2013)
Previous studies have shown that secondhand smoke induces lung function impairment and increases proinflammatory cytokines. The aim of the present study was to evaluate the acute effects of secondhand smoke on airway ...
Plasma leptin and adiponectin in COPD exacerbations: Associations with inflammatory biomarkers
(2010)
Background: Various systemic inflammatory markers have been evaluated for their value in acute exacerbations of chronic obstructive pulmonary disease (COPD). Leptin and adiponectin have been linked to acute exacerbations ...