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Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study
(2011)
Objectives The genetic aetiology of osteoarthritis has not yet been elucidated. To enable a well-powered genome-wide association study (GWAS) for osteoarthritis, the authors have formed the arcOGEN Consortium, a UK-wide ...
Deep sequencing of GDF5 reveals the absence of rare variants at this important osteoarthritis susceptibility locus
(2011)
Objective: The common single nucleotide polymorphism (SNP) rs143383 in the 5' untranslated region (5'UTR) of growth and differentiation factor 5 (GDF5) is strongly associated with osteoarthritis (OA) and influences GDF5 ...