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Gilbert Syndrome as a Predisposing Factor for Cholelithiasis Risk in the Greek Adult Population

Tsezou, A.; Tzetis, M.; Giannatou, E.; Spanos, I.; Roma, E.; Fretzayas, A.; Kanavakis, E.; Kitsiou-Tzeli, S. (2009)

We investigated the hypothesis that coinheritance of the common A(TA)(n)TAA promoter mutation at the UGT1A1 locus associated with Gilbert syndrome is a risk factor for gallstone formation in a homogeneous adult population, ...

The involvement of HER2 and p53 status in the regulation of telomerase in irradiated breast cancer cells

Papanikolaou, V.; Iliopoulos, D.; Dimou, I.; Dubos, S.; Tsougos, I.; Theodorou, K.; Kitsiou-Tzeli, S.; Tsezou, A. (2009)

Cancer cell characteristics may play a pivotal role in the response to therapy by activating or deactivating different molecular pathways. In the present study, we investigated the implication of breast cancer cell features, ...

hTERT regulation by NF-kappa B and c-myc in irradiated HER2-positive breast cancer cells

Papanikolaou, V.; Athanassiou, E.; Dubos, S.; Dimou, I.; Papathanasiou, I.; Kitsiou-Tzeli, S.; Kappas, C.; Tsezou, A. (2011)

Purpose: Telomerase activity (TA), frequently observed in cancer, compensates for telomere shortening thus preventing cell senescence and conferring resistance to therapy. In the present study, we investigated the expression ...

Survivin regulation by HER2 through NF-kappa B and c-myc in irradiated breast cancer cells

Papanikolaou, V.; Iliopoulos, D.; Dimou, I.; Dubos, S.; Kappas, C.; Kitsiou-Tzeli, S.; Tsezou, A. (2011)

Radiotherapy is an important treatment modality against cancer resulting in apoptosis and inhibition of cell growth. Survivin is an important cancer biomarker conferring to tumour cells increased survival potential by ...

Genetic Polymorphisms in the UGT1A1 gene and breast cancer risk in Greek women

Tsezou, A.; Tzetis, M.; Giannatou, E.; Gennatas, C.; Pampanos, A.; Kanavakis, E.; Kitsiou-Tzeli, S. (2007)

Uridine diphospho-glucuronosyltransferase 1 (UGT1A1) is involved in estradiol glucuronidation, which may play a central role in the etiology of breast cancer. A common insertion/ deletion polymorphism in the TATAA-box of ...

Influence of Interleukin 1 alpha (IL-1 alpha), IL-4, and IL-6 Polymorphisms on Genetic Susceptibility to Chronic Osteomyelitis

Tsezou, A.; Poultsides, L.; Kostopoulou, F.; Zintzaras, E.; Satra, M.; Kitsiou-Tzeli, S.; Malizos, K. N. (2008)

The association between cytokine gene polymorphisms and chronic osteomyelitis was investigated in order to determine whether genetic variability in cytokine genes predisposes to osteomyelitis susceptibility. Significant ...

Steroid hormones polymorphisms and cholelithiasis in Greek population

Kitsiou-Tzeli, S.; Giannatou, E.; Spanos, I.; Nicolaidou, P.; Fretzayas, A.; Tzetis, M.; Lazaris, D.; Kanavakis, E.; Tsezou, A. (2007)

Background: Genetic variation in genes involved in steroid biosynthesis, metabolism and signal transduction have been suggested to play a role in gallstone disease. Methods: To elucidate the possible role of genetic variation ...

Gilbert's syndrome as a predisposing factor for idiopathic cholelithiasis in children

Kitsiou-Tzeli, S.; Kanavakis, E.; Tzetis, M.; Kavazarakis, E.; Galla, A.; Tsezou, A. (2003)

Clinical and molecular description of a fetus in prenatal diagnosis with a rare de novo ring 10 and deletions of 12.59 Mb in 10p15.3-p14 and 4.22 Mb in 10q26.3

Christopoulou, G.; Tzetis, M.; Konstantinidou, A. E.; Tsezou, A.; Kanavakis, E.; Kitsiou-Tzeli, S.; Velissariou, V. (2012)

Ring chromosomes are rare cytogenetic findings and are mostly associated with an abnormal phenotype. We report on the prenatal diagnosis of a ring chromosome 10 in a fetus in which talipes equinovarus was incidentally found ...

The c.504T > C (p.Asn168Asn) polymorphism in the ABCB4 gene as a predisposing factor for intrahepatic cholestasis of pregnancy in Greece

Kitsiou-Tzeli, S.; Traeger-Synodinos, J.; Giannatou, E.; Kaminopetros, P.; Roma, E.; Makrythanasis, P.; Tsezou, A. (2010)